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    DLD1 D-lactate dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851380, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DLD1
    Official Full Name
    D-lactate dehydrogenase
    Primary source
    SGD:S000002333
    Locus tag
    YDL174C
    See related
    AllianceGenome:SGD:S000002333; FungiDB:YDL174C; VEuPathDB:YDL174C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-lactate dehydrogenase (cytochrome) activity. Involved in lactate catabolic process. Located in mitochondrial inner membrane. Orthologous to human LDHD (lactate dehydrogenase D). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DLD1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (145826..147589, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Gid12p Neighboring gene TRAMP complex RNA-binding subunit Neighboring gene Par32p Neighboring gene glutamate synthase (NADH)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sorting of D-lactate dehydrogenase to the inner membrane of mitochondria. Analysis of topogenic signal and energetic requirements. Rojo EE, et al. J Biol Chem, 1998 Apr 3. PMID 9525904
    2. Isolation of the DLD gene of Saccharomyces cerevisiae encoding the mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase. Lodi T, et al. Mol Gen Genet, 1993 Apr. PMID 8492799
    3. Kinetic activation of yeast mitochondrial D-lactate dehydrogenase by carboxylic acids. Mourier A, et al. Biochim Biophys Acta, 2008 Oct. PMID 18640090
    4. Kinetic properties of yeast D(-)-lactic cytochrome c reductase. NYGAARD AP. J Biol Chem, 1961 Jul. PMID 13729967
    5. Redirection of pyruvate flux toward desired metabolic pathways through substrate channeling between pyruvate kinase and pyruvate-converting enzymes in Saccharomyces cerevisiae. Kim S, et al. Sci Rep, 2016 Apr 7. PMID 27052099, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-lactate dehydrogenase (cytochrome) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-lactate dehydrogenase (cytochrome) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-lactate dehydrogenase (cytochrome) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables D-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lactate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lactate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-lactate dehydrogenase
    NP_010107.1
    • Major mitochondrial D-lactate dehydrogenase; oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      145826..147589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180234.1 → NP_010107.1  TPA: D-lactate dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010107.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRH8, P32891, Q12360
      UniProtKB/TrEMBL
      A6ZXF7, B3LH58, C7GL20, C8Z6D0, G2WBZ1, N1P5Q4
      Conserved Domains (1) summary
      PLN02805
      Location:49 → 574
      PLN02805; D-lactate dehydrogenase [cytochrome]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32891.2

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