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    UBC5 E2 ubiquitin-conjugating protein UBC5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851631, updated on 9-Dec-2024

    Summary

    Official Symbol
    UBC5
    Official Full Name
    E2 ubiquitin-conjugating protein UBC5
    Primary source
    SGD:S000002466
    Locus tag
    YDR059C
    See related
    AllianceGenome:SGD:S000002466; FungiDB:YDR059C; VEuPathDB:YDR059C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables proteasome binding activity and ubiquitin-protein transferase activity. Involved in protein polyubiquitination. Predicted to be active in nucleus. Orthologous to human UBE2D1 (ubiquitin conjugating enzyme E2 D1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See UBC5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_001136.10 (569234..569770, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene tRNA-Asp Neighboring gene RNA-binding ribosome biosynthesis protein MAK21 Neighboring gene uncharacterized protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables proteasome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E2 ubiquitin-conjugating protein UBC5
    NP_010344.1
    • Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      569234..569770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180367.1NP_010344.1  TPA: E2 ubiquitin-conjugating protein UBC5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010344.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS45, P15732
      UniProtKB/TrEMBL
      A6ZY24, B3LGL0, C8Z4X8, G2WAG3, N1PAC4
      Conserved Domains (1) summary
      cl00154
      Location:3147
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...