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    PAK5 p21 (RAC1) activated kinase 5 [ Homo sapiens (human) ]

    Gene ID: 57144, updated on 28-Dec-2024

    Summary

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    Official Symbol
    PAK5provided by HGNC
    Official Full Name
    p21 (RAC1) activated kinase 5provided by HGNC
    Primary source
    HGNC:HGNC:15916
    See related
    Ensembl:ENSG00000101349 MIM:608038; AllianceGenome:HGNC:15916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAK7
    Summary
    The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 4.1), adrenal (RPKM 1.0) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See PAK5 in Genome Data Viewer
    Location:
    20p12.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (9537370..9839076, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (9580273..9881978, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (9518017..9819724, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:9055836-9056336 Neighboring gene Sharpr-MPRA regulatory region 7247 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:9160877-9161492 Neighboring gene phospholipase C beta 4 Neighboring gene MPRA-validated peak4143 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:9496172-9496756 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:9499300-9500006 Neighboring gene LAMP5 antisense RNA 1 Neighboring gene uncharacterized LOC105372523 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:9553223-9553723 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:9557290-9557799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17538 Neighboring gene uncharacterized LOC101929348 Neighboring gene lysosomal associated membrane protein family member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17540 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:9958069-9959268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12670 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:10028171-10028363 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:10029614-10030813 Neighboring gene SNAP25 antisense RNA 1 Neighboring gene PPARG activating RBM14 associated lncRNA 1 Neighboring gene ankyrin repeat and EF-hand domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Cotteret S, et al. Mol Cell Biol, 2006 Apr. PMID 16581795, Free PMC Article
    2. PAK5 Induces EMT and Promotes Cell Migration and Invasion by Activating the PI3K/AKT Pathway in Ovarian Cancer. Li D, et al. Anal Cell Pathol (Amst), 2018. PMID 30245957, Free PMC Article
    3. High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma. Li C, et al. Oncotarget, 2016 Jul 19. PMID 27323857, Free PMC Article
    4. PAK5 is auto-activated by a central domain that promotes kinase oligomerization. Tabanifar B, et al. Biochem J, 2016 Jun 15. PMID 27095851
    5. Human p21-activated kinase 5 (PAK5) expression and potential mechanisms in relevant cancers: Basic and clinical perspectives for molecular cancer therapeutics. Li YK, et al. Life Sci, 2020 Jan 15. PMID 31805288

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAK5 potentiates slug transactivation of N-cadherin to facilitate metastasis of renal cell carcinoma.
      Title: PAK5 potentiates slug transactivation of N-cadherin to facilitate metastasis of renal cell carcinoma.
    2. PAK5 is a potential target in myelodysplastic syndrome through interacting with LMO2 and GATA1.
      Title: PAK5 is a potential target in myelodysplastic syndrome through interacting with LMO2 and GATA1.
    3. The Predictive Value of PAK7 Mutation for Immune Checkpoint Inhibitors Therapy in Non-Small Cell Cancer.
      Title: The Predictive Value of PAK7 Mutation for Immune Checkpoint Inhibitors Therapy in Non-Small Cell Cancer.
    4. Inhibiting p21-activated kinase (PAK7) enhances radiosensitivity in hepatocellular carcinoma.
      Title: Inhibiting p21-activated kinase (PAK7) enhances radiosensitivity in hepatocellular carcinoma.
    5. P21-activated kinase 5 potentiates the chemoresistant phenotype of liver cancer.
      Title: P21-activated kinase 5 potentiates the chemoresistant phenotype of liver cancer.
    6. PAK5 promotes RNA helicase DDX5 sumoylation and miRNA-10b processing in a kinase-dependent manner in breast cancer.
      Title: PAK5 promotes RNA helicase DDX5 sumoylation and miRNA-10b processing in a kinase-dependent manner in breast cancer.
    7. PAK5-stabilized Smuc confers renal cell carcinoma metastasis.
      Title: PAK5-stabilized Smuc confers renal cell carcinoma metastasis.
    8. MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating beta-catenin signaling in hyperlipidemia.
      Title: MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia.
    9. Prognostic significance of PAK family kinases in acute myeloid leukemia.
      Title: Prognostic significance of PAK family kinases in acute myeloid leukemia.
    10. Bioinformatic analysis of the potential molecular mechanism of PAK7 expression in glioblastoma.
      Title: Bioinformatic analysis of the potential molecular mechanism of PAK7 expression in glioblastoma.
    Submit: New GeneRIF Correction See all GeneRIFs (42)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1264, MGC26232

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in learning IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell growth TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 5
    Names
    PAK-5
    PAK-7
    p21 (RAC1) activated kinase 7
    p21 protein (Cdc42/Rac)-activated kinase 7
    p21(CDKN1A)-activated kinase 7
    p21-activated kinase 5
    p21-activated kinase 7
    p21CDKN1A-activated kinase 7
    protein kinase PAK5
    serine/threonine-protein kinase PAK 7
    serine/threonine-protein kinase PAK7
    NP_065074.1
    NP_817127.1
    XP_016883449.1
    XP_016883450.1
    XP_016883451.1
    XP_016883453.1
    XP_016883454.1
    XP_054179701.1
    XP_054179702.1
    XP_054179703.1
    XP_054179704.1
    XP_054179705.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020341.5 → NP_065074.1  serine/threonine-protein kinase PAK 5

      See identical proteins and their annotated locations for NP_065074.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. This variant and variant 2 encode the same protein.
      Source sequence(s)
      AB033090, AB040812, AK315820, AL031652, AL034427
      Consensus CDS
      CCDS13107.1
      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Related
      ENSP00000367686.3, ENST00000378429.3
      Conserved Domains (2) summary
      cd06658
      Location:426 → 717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:9 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    2. NM_177990.4 → NP_817127.1  serine/threonine-protein kinase PAK 5

      See identical proteins and their annotated locations for NP_817127.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal 5' UTR exon, as compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AB040812, AK307926, AK315820, AL031652, AL034427
      Consensus CDS
      CCDS13107.1
      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Related
      ENSP00000322957.5, ENST00000353224.10
      Conserved Domains (2) summary
      cd06658
      Location:426 → 717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:9 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      9537370..9839076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027960.2 → XP_016883449.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Conserved Domains (2) summary
      cd06658
      Location:426 → 717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:9 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    2. XM_017027961.2 → XP_016883450.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Conserved Domains (2) summary
      cd06658
      Location:426 → 717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:9 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    3. XM_017027962.2 → XP_016883451.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Conserved Domains (2) summary
      cd06658
      Location:426 → 717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:9 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    4. XM_017027964.2 → XP_016883453.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Conserved Domains (2) summary
      cd06658
      Location:426 → 717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:9 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    5. XM_017027965.2 → XP_016883454.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Conserved Domains (2) summary
      cd06658
      Location:426 → 717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:9 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      9580273..9881978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323727.1 → XP_054179702.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9

    2. XM_054323728.1 → XP_054179703.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9

    3. XM_054323726.1 → XP_054179701.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9

    4. XM_054323729.1 → XP_054179704.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9

    5. XM_054323730.1 → XP_054179705.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P286.1 GenPept UniProtKB/Swiss-Prot:Q9P286

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