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    folP dihydropteroate synthase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 881715, updated on 24-Aug-2024

    Summary

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    Gene symbol
    folP
    Gene description
    dihydropteroate synthase
    Locus tag
    PA4750
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5334921..5335772, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene triosephosphate isomerase Neighboring gene phosphoglucosamine mutase Neighboring gene cell division protein FtsH Neighboring gene cell division protein FtsJ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, sequencing, and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100. Dallas WS, et al. J Bacteriol, 1992 Sep. PMID 1522070, Free PMC Article
    2. Purification and partial characterization of 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase and 7,8-dihydropteroate synthase from Escherichia coli MC4100. Talarico TL, et al. J Bacteriol, 1991 Nov. PMID 1657875, Free PMC Article
    3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables dihydropteroate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydropteroate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within folic acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydropteroate synthase
    NP_253438.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5334921..5335772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253438.1 dihydropteroate synthase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253438.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3M5EE89
      Conserved Domains (1) summary
      cl00219
      Location:15 → 282
      Pterin_binding; Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a ...
    Nucleotide Protein
    Heading Accession and Version

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