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    CG16758 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38315, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG16758provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035348
    Locus tag
    Dmel_CG16758
    See related
    AllianceGenome:FB:FBgn0035348
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c62E-15; CG16760; Dmel\CG16758
    Summary
    Predicted to enable purine-nucleoside phosphorylase activity. Involved in imaginal disc fusion, thorax closure. Predicted to be active in cytoplasm. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG16758 in Genome Data Viewer
    Location:
    62E4-62E4; 3-3 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2499372..2503606, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2499372..2503606, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Supervillin Neighboring gene Cytochrome P450 4d20 Neighboring gene long non-coding RNA:CR45425 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45170 Neighboring gene Spinophilin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 62E early-late puff of Drosophila contains D-spinophilin, an ecdysone-inducible PDZ-domain protein dynamically expressed during metamorphosis. Keegan J, et al. Genet Res, 2001 Feb. PMID 11279828
    2. PRPS-Associated Disorders and the Drosophila Model of Arts Syndrome. Delos Santos K, et al. Int J Mol Sci, 2020 Jul 8. PMID 32650483, Free PMC Article
    3. Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function. Muhammad K, et al. Nat Commun, 2015 Oct 16. PMID 26471740, Free PMC Article
    4. The Tbx6 Transcription Factor Dorsocross Mediates Dpp Signaling to Regulate Drosophila Thorax Closure. Lu J, et al. Int J Mol Sci, 2022 Apr 20. PMID 35562934, Free PMC Article
    5. dGLYAT modulates Gadd45-mediated JNK activation and cell invasion. Xu M, et al. Cell Div, 2022 Aug 6. PMID 35933447, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables purine-nucleoside phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-nucleoside phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc fusion, thorax closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG16758-PB
    CG16758-PD
    CG16758-PE
    CG16758-PF
    CG16758-PG
    CG16758-PH
    NP_001246569.1
    NP_001261330.1
    NP_647727.2
    NP_728752.1
    NP_995969.1
    NP_995970.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2499372..2503606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167952.3 → NP_728752.1  uncharacterized protein Dmel_CG16758, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKM8, Q9W004, Q9W005, Q9W006, Q9W007
      Related
      FBpp0072834
      Conserved Domains (2) summary
      COG0005
      Location:49 → 324
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      PRK08202
      Location:46 → 324
      PRK08202; purine nucleoside phosphorylase; Provisional

    2. NM_139470.4 → NP_647727.2  uncharacterized protein Dmel_CG16758, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647727.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKM8, Q7KV94
      Related
      FBpp0072833
      Conserved Domains (2) summary
      COG0005
      Location:73 → 348
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      PRK08202
      Location:70 → 348
      PRK08202; purine nucleoside phosphorylase; Provisional

    3. NM_001259640.2 → NP_001246569.1  uncharacterized protein Dmel_CG16758, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKM8, M9ND26
      Conserved Domains (2) summary
      COG0005
      Location:92 → 367
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      PRK08202
      Location:89 → 367
      PRK08202; purine nucleoside phosphorylase; Provisional

    4. NM_001274401.1 → NP_001261330.1  uncharacterized protein Dmel_CG16758, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261330.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKM8, M9PE19
      Conserved Domains (2) summary
      COG0005
      Location:116 → 391
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      PRK08202
      Location:113 → 391
      PRK08202; purine nucleoside phosphorylase; Provisional

    5. NM_206247.2 → NP_995969.1  uncharacterized protein Dmel_CG16758, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995969.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKM8, Q7KV95
      Conserved Domains (2) summary
      COG0005
      Location:48 → 323
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      PRK08202
      Location:45 → 323
      PRK08202; purine nucleoside phosphorylase; Provisional

    6. NM_206248.2 → NP_995970.1  uncharacterized protein Dmel_CG16758, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKM8, Q7KV91
      Conserved Domains (2) summary
      COG0005
      Location:41 → 316
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      PRK08202
      Location:38 → 316
      PRK08202; purine nucleoside phosphorylase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9ND26 M9ND26
    M9PE19 M9PE19
    Q7KV91 Q7KV91
    Q7KV94 Q7KV94
    Q7KV95 Q7KV95
    Q95TC1 Q95TC1
    Q9W004 Q9W004

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