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    betaTub85D beta-Tubulin at 85D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41124, updated on 17-Dec-2024

    Summary

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    Official Symbol
    betaTub85Dprovided by FlyBase
    Official Full Name
    beta-Tubulin at 85Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003889
    Locus tag
    Dmel_CG9359
    See related
    AllianceGenome:FB:FBgn0003889
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2t; B2t; BETA 85D; beta(2)Tu; beta(2)Tub; beta-tub; beta-tub85D; beta-Tub85D; beta2; BETA2; beta2-tub; beta2t; beta2tub; beta85D; beta;Tub85D; betaTub; betaTub2; betatub85D; Betatub85D; BetaTub85D; betatubulin; beta[[2]]-tubulin; CG9359; D.m.BETA-85D; Dmbeta2; Dmel\CG9359; DTB4; FBgn0003889; ms(3)KK[D]; Tub; Tub2A; TUBB2A
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in salivary gland morphogenesis. Predicted to be active in cytoplasm and microtubule. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 5. Orthologous to human TUBB2A (tubulin beta 2A class IIa). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See betaTub85D in Genome Data Viewer
    Location:
    85D15-85D15; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9408383..9410282, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5234105..5236004, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene BBSome interacting protein 1 Neighboring gene uncharacterized protein Neighboring gene TWIK-related acid-sensitive K[+] channel 7 Neighboring gene alpha-Mannosidase class II a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The proximal region of the beta-tubulin C-terminal tail is sufficient for axoneme assembly. Popodi EM, et al. Cell Motil Cytoskeleton, 2005 Sep. PMID 16080206
    2. The initiator element of the Drosophila beta2 tubulin gene core promoter contributes to gene expression in vivo but is not required for male germ-cell specific expression. Santel A, et al. Nucleic Acids Res, 2000 Mar 15. PMID 10684940, Free PMC Article
    3. Mammalian DNMTs in the male germ line DNA of Drosophila. Weyrich A, et al. Biochem Cell Biol, 2008 Oct. PMID 18923539
    4. Genetic analysis of microtubule structure: a beta-tubulin mutation causes the formation of aberrant microtubules in vivo and in vitro. Fuller MT, et al. J Cell Biol, 1987 Mar. PMID 3818786, Free PMC Article
    5. Characterization of the Drosophila suzukii β2-tubulin gene and the utilization of its promoter to monitor sex separation and insemination. Yan Y, et al. Gene, 2021 Mar 1. PMID 33346099

    See all (221) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. beta2t plays an important role in salivary gland and myoblast migration
      Title: Deficiency screen identifies a novel role for beta 2 tubulin in salivary gland and myoblast migration in the Drosophila embryo.
    2. Partially truncated beta2-tubulin (beta2Delta7) containing only the proximal portion of the C-terminal tail, including the axoneme motif, can support production of functional motile sperm.
      Title: The proximal region of the beta-tubulin C-terminal tail is sufficient for axoneme assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in salivary gland morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-Tubulin at 85D
    Names
    CG9359-PA
    b2 tubulin
    beta 2 tubulin
    beta tubulin
    beta(2)Tubulin
    beta-Tubulin
    beta-Tubulin 85D
    beta-tubulin85D
    beta2 tubulin
    beta2-tubulin
    beta2tubulin
    betaTub85D-PA
    betaTubulin85D
    testis-specific beta-tubulin
    tubulin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9408383..9410282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079566.4 → NP_524290.2  beta-Tubulin at 85D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524290.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P61857, Q540X8
      UniProtKB/TrEMBL
      E0R982
      Related
      FBpp0081524
      Conserved Domains (1) summary
      PLN00220
      Location:1 → 430
      PLN00220; tubulin beta chain; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61857.1 P61857

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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