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    P5cr Pyrroline 5-carboyxlate reductase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42284, updated on 9-Dec-2024

    Summary

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    Official Symbol
    P5crprovided by FlyBase
    Official Full Name
    Pyrroline 5-carboyxlate reductaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015781
    Locus tag
    Dmel_CG6009
    See related
    AllianceGenome:FB:FBgn0015781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6009; Dmel\CG6009; P5CR
    Summary
    Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Is expressed in adult head; embryonic/larval garland cell; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See P5cr in Genome Data Viewer
    Location:
    91E4-91E4; 3-65 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19028931..19030159)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14854653..14855881)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glutamyl-tRNA amidotransferase, subunit A Neighboring gene NP15.6 Neighboring gene Prp18 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complementation cloning and characterization of the pyrroline 5-carboxylate reductase gene from Drosophila melanogaster. Misener SR, et al. Biochem Genet, 2001 Feb. PMID 11444018
    2. Cold tolerance and proline metabolic gene expression in Drosophila melanogaster. Misener SR, et al. J Insect Physiol, 2001 Apr. PMID 11166304
    3. Extraordinarily high density of unrelated genes showing overlapping and intraintronic transcription units. Misener SR, et al. Biochim Biophys Acta, 2000 Jun 21. PMID 10858562
    4. Mutations in the Drosophila mitochondrial tRNA amidotransferase, bene/gatA, cause growth defects in mitotic and endoreplicating tissues. Morris JZ, et al. Genetics, 2008 Feb. PMID 18245325, Free PMC Article
    5. Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4. Baltzer C, et al. PLoS One, 2009 Sep 9. PMID 19742324, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables pyrroline-5-carboxylate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyrroline 5-carboyxlate reductase
    Names
    CG6009-PA
    P5cr-PA
    pyrroline 5-carboxylate
    reductase
    NP_524400.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19028931..19030159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079676.4 → NP_524400.2  pyrroline 5-carboyxlate reductase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524400.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96643, Q9V3F8
      Related
      FBpp0083127
      Conserved Domains (3) summary
      COG0345
      Location:6 → 280
      ProC; Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]
      pfam03807
      Location:9 → 106
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
      pfam14748
      Location:172 → 276
      P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96643 O96643
    Q9V3F8 Q9V3F8

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