lectin-24A lectin-24A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: lectin-24Aprovided by FlyBase
Official Full Name: lectin-24Aprovided by FlyBase
Primary source: FLYBASE:FBgn0040104
Locus tag: Dmel_CG3410
See related: AllianceGenome:FB:FBgn0040104
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AC 005149A; AC005149a; CG3410; Dmel\CG3410; Lectin-24A
Summary: Predicted to enable galactose binding activity and pattern recognition receptor activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules and induction of bacterial agglutination. Predicted to be located in extracellular region. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in 3MC syndrome 3; asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to several human genes including COLEC10 (collectin subfamily member 10); SFTPA1 (surfactant protein A1); and SFTPA2 (surfactant protein A2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3716800..3717773, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3716800..3717773, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables galactose binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in induction of bacterial agglutination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISM Inferred from Sequence Model more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain