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    crok crooked [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crokprovided by FlyBase
    Official Full Name
    crookedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032421
    Locus tag
    Dmel_CG17218
    See related
    AllianceGenome:FB:FBgn0032421
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE65321; CG17218; Dmel\CG17218
    Summary
    Involved in regulation of tube size, open tracheal system and septate junction assembly. Located in cytoplasm. Is expressed in several structures, including adult head; adult heart; clypeo-labral primordium; epithelium; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See crok in Genome Data Viewer
    Location:
    33D2-33D2; 2-46 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12172981..12174091)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12172981..12174091)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43356 Neighboring gene Zinc transporter 33D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene atilla Neighboring gene bruno 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multispecies Analysis of Expression Pattern Diversification in the Recently Expanded Insect Ly6 Gene Family. Tanaka K, et al. Mol Biol Evol, 2015 Jul. PMID 25743545, Free PMC Article
    2. Occluding junctions as novel regulators of tissue mechanics during wound repair. Carvalho L, et al. J Cell Biol, 2018 Dec 3. PMID 30228162, Free PMC Article
    3. The apical plasma membrane of chitin-synthesizing epithelia. Moussian B. Insect Sci, 2013 Apr. PMID 23955854
    4. Boudin trafficking reveals the dynamic internalisation of specific septate junction components in Drosophila. Tempesta C, et al. PLoS One, 2017. PMID 28977027, Free PMC Article
    5. Macroglobulin complement-related encodes a protein required for septate junction organization and paracellular barrier function in Drosophila. Hall S, et al. Development, 2014 Feb. PMID 24496625, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in positive regulation of voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic transmission, cholinergic IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sleep IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    crooked
    Names
    CG17218-PA
    crok-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12172981..12174091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135713.3 → NP_609557.1  crooked [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609557.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYE3, Q9VKA0
      Related
      FBpp0079924
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYE3 Q8SYE3
    Q9VKA0 Q9VKA0
    Q9VKA0.1

    Gene LinkOut

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