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    Ance-2 Ance-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34806, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ance-2provided by FlyBase
    Official Full Name
    Ance-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0032535
    Locus tag
    Dmel_CG16869
    See related
    AllianceGenome:FB:FBgn0032535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ance-2; CG16869; CG31844; Dmel\CG16869
    Summary
    Predicted to be located in membrane. Predicted to be active in extracellular space and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ance-2 in Genome Data Viewer
    Location:
    34E2-34E2; 2-50 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13909333..13911719)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13909333..13911719)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Smg5 nonsense mediated mRNA decay factor Neighboring gene Angiotensin converting enzyme Neighboring gene Acylphosphatase Neighboring gene Ance-3 Neighboring gene Vajk1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ACE and ACE2: insights from Drosophila and implications for COVID-19. Herrera P, et al. Heliyon, 2021 Dec. PMID 34901515, Free PMC Article
    2. Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme. Coates D, et al. Biochemistry, 2000 Aug 1. PMID 10913309
    3. A conserved gene cluster as a putative functional unit in insect innate immunity. Somogyi K, et al. FEBS Lett, 2010 Nov 5. PMID 20951134
    4. Drosophila in asthma research. Roeder T, et al. Am J Respir Crit Care Med, 2009 Jun 1. PMID 19342413
    5. Nanopore Formation in the Cuticle of an Insect Olfactory Sensillum. Ando T, et al. Curr Biol, 2019 May 6. PMID 31006566

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables metallopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables peptidyl-dipeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in proteolysis IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ance-2
    Names
    Ance-2-PA
    CG16869-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13909333..13911719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176028.2 → NP_788042.1  Ance-2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788042.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJV2
      Related
      FBpp0080131
      Conserved Domains (1) summary
      cl14813
      Location:26 → 601
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJV2 Q9VJV2

    Gene LinkOut

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