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    ksh kish [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50363, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kshprovided by FlyBase
    Official Full Name
    kishprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040890
    Locus tag
    Dmel_CG14199
    See related
    AllianceGenome:FB:FBgn0040890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14199; Dmel\CG14199
    Summary
    Involved in intracellular transport and protein secretion. Located in Golgi apparatus and endoplasmic reticulum. Orthologous to human TMEM167A (transmembrane protein 167A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ksh in Genome Data Viewer
    Location:
    18C8-18C8; 1-62 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19494420..19494992, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19388453..19389025, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pacman Neighboring gene antisense RNA:CR44340 Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 18 kDa subunit Neighboring gene uncharacterized protein Neighboring gene 6-phosphofructo-2-kinase Neighboring gene Isocitrate dehydrogenase 3a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oncogenic dependence of glioma cells on kish/TMEM167A regulation of vesicular trafficking. Portela M, et al. Glia, 2019 Feb. PMID 30506943
    2. Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competition. Casas-Tintó S, et al. Nat Commun, 2015 Dec 11. PMID 26658841
    3. Ligand-independent requirements of steroid receptors EcR and USP for cell survival. Mansilla A, et al. Cell Death Differ, 2016 Mar. PMID 26250909, Free PMC Article
    4. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. Wendler F, et al. EMBO J, 2010 Jan 20. PMID 19942856, Free PMC Article
    5. Systems genetics of complex traits in Drosophila melanogaster. Ayroles JF, et al. Nat Genet, 2009 Mar. PMID 19234471, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kish
    Names
    CG14199-PB
    ksh-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19494420..19494992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144242.4 → NP_652499.2  kish [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652499.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWH8
      UniProtKB/TrEMBL
      A0A1B2AJU4
      Conserved Domains (1) summary
      pfam06842
      Location:19 → 44
      DUF1242; Protein of unknown function (DUF1242)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWH8.2 Q9VWH8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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