emb embargoed [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: embprovided by FlyBase
Official Full Name: embargoedprovided by FlyBase
Primary source: FLYBASE:FBgn0020497
Locus tag: Dmel_CG13387
See related: AllianceGenome:FB:FBgn0020497
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13387; CRM-1; crm1; Crm1; CRM1; dCRM1; DCRM1; Dmel\CG13387; dXPO1; Emb; EN2-1; l(2)k16715; XPO-1; xpo1; Xpo1; XPO1
Summary: Enables nuclear export signal receptor activity. Involved in several processes, including centriole replication; nuclear export; and nuclear pore complex assembly. Located in nuclear membrane. Part of nuclear pore. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; ganglia; gut section; and somatic muscle cell. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 29C1-29C3; 2-32 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8403573..8408853)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8403573..8408853)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nucleoporin 154 and Exportin1 (XPO1) prevented FUS-induced neurotoxicity. Moreover, we show that XPO1 interacted with FUS. Silencing XPO1 significantly reduced the propensity of FUS to form inclusions upon stress.
Title: FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins.
two newly identified factors that restrict diverse viruses, dXPO1 and dRUVBL1 contributed to antiviral defense at the organismal level in adult flies
Title: Genome-wide RNAi screen identifies broadly-acting host factors that inhibit arbovirus infection.
Nuclear export of TIS11 proteins is mediated by CRM1 through diverging nuclear export signals, while their nuclear import mechanism may rely on a highly conserved signal whose activity is negatively regulated by ZnF2 folding.
Title: A masked PY-NLS in Drosophila TIS11 and its mammalian homolog tristetraprolin.
HPO promotes the translocation of SD to the cytoplasm in a CRM1-dependent manner
Title: The Hippo kinase promotes Scalloped cytoplasmic localization independently of Warts in a CRM1/Exportin1-dependent manner in Drosophila.
Exportin-1 is a nuclear export receptor for expanded polyQ containing proteins.
Title: Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1.
Nuclear localization of the ecdysteroid receptor (EcR) is increased in HeLa cells if exportin-1 (CRM1) is knocked down by siRNA against exportin.
Title: The importance of exportin and Ran for nucleocytoplasmic shuttling of the ecdysteroid receptor.
two functional nuclear export signals are in the Sima basic helix-loop-helix (bHLH) domain and promote CRM1-dependent nuclear export
Title: Regulation of the Drosophila hypoxia-inducible factor alpha Sima by CRM1-dependent nuclear export.
Phosphorylation of Yan favors Crm1 in this competition and counteracts inhibition of nuclear export by Mae
Title: Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response.
A major function of DNup88 is to anchor DNup214 and CRM1 on the nuclear envelope and thereby attenuate NES-mediated nuclear export.
Title: The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear export.
Data show that downregulation of YAN involves CRM1-mediated nuclear export, and that MAE is involved in MAPK phosphorylationof YAN.
Title: CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables nuclear export signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear export signal receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear export signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear export signal receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear export	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear pore complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: embargoed

Names: CG13387-PA; CG13387-PB; Exportin-1; chromosomal region maintenance 1; emb-PA; emb-PB; enhancer of NA9 2-1; exportin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

8403573..8408853

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164818.2 → NP_723391.2 embargoed, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723391.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9I7N7, Q9TVM2, Q9U699

UniProtKB/TrEMBL

A0A0S0WNN6

Related

FBpp0079278

Conserved Domains (4) summary

smart00913
Location:43 → 109

IBN_N; Importin-beta N-terminal domain

COG5101
Location:13 → 1023

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

pfam08389
Location:120 → 265

Xpo1; Exportin 1-like protein

pfam08767
Location:701 → 1015

CRM1_C; CRM1 C terminal
NM_001316387.1 → NP_001303316.1 embargoed, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9I7N7, Q9TVM2, Q9U699

UniProtKB/TrEMBL

A0A0S0WNN6

Conserved Domains (4) summary

smart00913
Location:43 → 109

IBN_N; Importin-beta N-terminal domain

COG5101
Location:13 → 1023

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

pfam08389
Location:120 → 265

Xpo1; Exportin 1-like protein

pfam08767
Location:701 → 1015

CRM1_C; CRM1 C terminal