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    TP53INP Tumor protein p53 inducible nuclear protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38543, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TP53INPprovided by FlyBase
    Official Full Name
    Tumor protein p53 inducible nuclear proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035542
    Locus tag
    Dmel_CG11347
    See related
    AllianceGenome:FB:FBgn0035542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11347; dDOR; Dmel\CG11347; DOR
    Summary
    Enables nuclear receptor binding activity and nuclear receptor coactivator activity. Involved in several processes, including ecdysone receptor signaling pathway; positive regulation of ecdysone receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Predicted to be active in autophagosome and nucleus. Is expressed in several structures, including CNS glial cell; head epidermis primordium; sensory nervous system primordium; ventral nerve cord; and visceral mesoderm derivative. Orthologous to human TP53INP1 (tumor protein p53 inducible nuclear protein 1) and TP53INP2 (tumor protein p53 inducible nuclear protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TP53INP in Genome Data Viewer
    Location:
    64B4-64B5; 3-12 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4406943..4420648)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4406943..4420648)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene slowdown Neighboring gene Syntaxin 17 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nicotinic Acetylcholine Receptor beta1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TP53INP1 exerts neuroprotection under ageing and Parkinson's disease-related stress condition. Dinh E, et al. Cell Death Dis, 2021 May 8. PMID 33966044, Free PMC Article
    2. The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells. Mauvezin C, et al. EMBO Rep, 2010 Jan. PMID 20010805, Free PMC Article
    3. Concurrent targeting of GSK3 and MEK as a therapeutic strategy to treat pancreatic ductal adenocarcinoma. Fukuda J, et al. Cancer Sci, 2024 Apr. PMID 38320747, Free PMC Article
    4. A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing. Lu YX, et al. Elife, 2021 May 14. PMID 33988501, Free PMC Article
    5. dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling. Francis VA, et al. Curr Biol, 2010 Oct 26. PMID 20888228

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ecdysone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ecdysone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor protein p53 inducible nuclear protein
    Names
    CG11347-PA
    CG11347-PB
    CG11347-PC
    CG11347-PD
    CG11347-PE
    CG11347-PF
    CG11347-PG
    CG11347-PH
    TP53INP-PA
    TP53INP-PB
    TP53INP-PC
    TP53INP-PD
    TP53INP-PE
    TP53INP-PF
    TP53INP-PG
    TP53INP-PH
    diabetes and obesity regulated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4406943..4420648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104033.2 → NP_001097503.1  tumor protein p53 inducible nuclear protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097503.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZC6, Q9VZC7
      Conserved Domains (1) summary
      pfam14839
      Location:111 → 376
      DOR; DOR family

    2. NM_168084.2 → NP_728991.1  tumor protein p53 inducible nuclear protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728991.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZC6, Q9VZC7
      Related
      FBpp0073150
      Conserved Domains (1) summary
      pfam14839
      Location:111 → 376
      DOR; DOR family

    3. NM_001259695.1 → NP_001246624.1  tumor protein p53 inducible nuclear protein, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFM7
      Conserved Domains (1) summary
      pfam14839
      Location:111 → 406
      DOR; DOR family

    4. NM_168083.3 → NP_728990.1  tumor protein p53 inducible nuclear protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728990.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZC6, Q9VZC7
      Related
      FBpp0073151
      Conserved Domains (1) summary
      pfam14839
      Location:111 → 376
      DOR; DOR family

    5. NM_001259696.2 → NP_001246625.1  tumor protein p53 inducible nuclear protein, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246625.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFM7
      Conserved Domains (1) summary
      pfam14839
      Location:111 → 406
      DOR; DOR family

    6. NM_139643.3 → NP_647900.1  tumor protein p53 inducible nuclear protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647900.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZC6, Q9VZC7
      Related
      FBpp0073152
      Conserved Domains (1) summary
      pfam14839
      Location:111 → 376
      DOR; DOR family

    7. NM_168085.2 → NP_728992.1  tumor protein p53 inducible nuclear protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728992.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN74, Q8IRB4
      Related
      FBpp0073153
      Conserved Domains (1) summary
      pfam14839
      Location:134 → 262
      DOR; DOR family

    8. NM_001104034.1 → NP_001097504.1  tumor protein p53 inducible nuclear protein, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097504.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNK7, Q6NN74
      Conserved Domains (1) summary
      pfam14839
      Location:90 → 218
      DOR; DOR family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNK7 A8JNK7
    M9NFM7 M9NFM7
    Q8IRB4 Q8IRB4
    Q9VZC7 Q9VZC7

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