Rpn2 Regulatory particle non-ATPase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rpn2provided by FlyBase
Official Full Name: Regulatory particle non-ATPase 2provided by FlyBase
Primary source: FLYBASE:FBgn0028692
Locus tag: Dmel_CG11888
See related: AllianceGenome:FB:FBgn0028692
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 11888; CG11888; Dmel\CG11888; dRpn2; p110; PSMC1; rpn2; RPN2; S1
Summary: Enables zinc ion binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in several structures, including adult head; adult heart; central brain primordium; ganglia; and spermatozoon. Orthologous to human PSMD1 (proteasome 26S subunit, non-ATPase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 98F13-98F13; 3-97 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29153524..29157255)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24979246..24982977)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, base subcomplex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in proteasome storage granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: regulatory particle non-ATPase 2

Names: CG11888-PA; CG11888-PB; CG11888-PC; Rpn2-PA; Rpn2-PB; Rpn2-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

29153524..29157255

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001276129.1 → NP_001263058.1 regulatory particle non-ATPase 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263058.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B5RIH8, Q8IGU4, Q8T075, Q9GSE5, Q9GU70, Q9V3P6

UniProtKB/TrEMBL

A0A0B4KHE9

Conserved Domains (3) summary

COG5116
Location:1 → 1003

RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

pfam01851
Location:666 → 701

PC_rep; Proteasome/cyclosome repeat

sd00044
Location:616 → 639

HEAT; HEAT repeat [structural motif]
NM_143420.3 → NP_651677.2 regulatory particle non-ATPase 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651677.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B5RIH8, Q8IGU4, Q8T075, Q9GSE5, Q9GU70, Q9V3P6

UniProtKB/TrEMBL

A0A0B4KHE9

Related

FBpp0084754

Conserved Domains (3) summary

COG5116
Location:1 → 1003

RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

pfam01851
Location:666 → 701

PC_rep; Proteasome/cyclosome repeat

sd00044
Location:616 → 639

HEAT; HEAT repeat [structural motif]
NM_001276128.1 → NP_001263057.1 regulatory particle non-ATPase 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263057.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KI10

Conserved Domains (3) summary

COG5116
Location:1 → 1003

RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

pfam01851
Location:666 → 701

PC_rep; Proteasome/cyclosome repeat

sd00044
Location:616 → 639

HEAT; HEAT repeat [structural motif]