DMAP1 DNA methyltransferase 1 associated protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: DMAP1provided by FlyBase
Official Full Name: DNA methyltransferase 1 associated protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0034537
Locus tag: Dmel_CG11132
See related: AllianceGenome:FB:FBgn0034537
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11132; dDMAP1; DMA; Dmel\CG11132; Q7K3D8_DROME
Summary: Predicted to enable transcription corepressor activity. Involved in DNA repair-dependent chromatin remodeling; positive regulation of antimicrobial peptide production; and positive regulation of innate immune response. Located in nucleus. Part of NuA4 histone acetyltransferase complex. Is expressed in organism. Orthologous to human DMAP1 (DNA methyltransferase 1 associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (20644036..20645865)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (16531541..16533370)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

these results reveal that DMAP1 is a novel nuclear modulator of the IMD pathway, possibly acting at the level of chromatin remodeling.
Title: The chromatin regulator DMAP1 modulates activity of the nuclear factor B (NF-B) transcription factor Relish in the Drosophila innate immune response.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair-dependent chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of antimicrobial peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of NuA4 histone acetyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of Swr1 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

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