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    CHO2 phosphatidylethanolamine N-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853061, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CHO2
    Official Full Name
    phosphatidylethanolamine N-methyltransferase
    Primary source
    SGD:S000003389
    Locus tag
    YGR157W
    See related
    AllianceGenome:SGD:S000003389; FungiDB:YGR157W; VEuPathDB:YGR157W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PEM1
    Summary
    Enables phosphatidylethanolamine N-methyltransferase activity. Involved in phosphatidylcholine biosynthetic process. Located in cell periphery and endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CHO2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (802440..805049)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene cystathionine beta-synthase CYS4 Neighboring gene cleavage polyadenylation factor subunit PTI1 Neighboring gene exosome non-catalytic core subunit MTR3 Neighboring gene Nsr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis. Hirsch JP, et al. Mol Cell Biol, 1986 Oct. PMID 3025587, Free PMC Article
    2. Saccharomyces cerevisiae cho2 mutants are deficient in phospholipid methylation and cross-pathway regulation of inositol synthesis. Summers EF, et al. Genetics, 1988 Dec. PMID 3066687, Free PMC Article
    3. Regulation of phosphatidylethanolamine methyltransferase level by myo-inositol in Saccaromyces cerevisiae. Yamashita S, et al. Eur J Biochem, 1980 Mar. PMID 6988218
    4. Identification of the upstream activation sequences responsible for the expression and regulation of the PEM1 and PEM2 genes encoding the enzymes of the phosphatidylethanolamine methylation pathway in Saccharomyces cerevisiae. Kodaki T, et al. J Biochem, 1991 Feb. PMID 1650774
    5. A pleiotropic phospholipid biosynthetic regulatory mutation in Saccharomyces cerevisiae is allelic to sin3 (sdi1, ume4, rpd1). Hudak KA, et al. Genetics, 1994 Feb. PMID 8150277, Free PMC Article

    See all (136) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylethanolamine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylethanolamine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylethanolamine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylethanolamine N-methyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables phosphatidylethanolamine N-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidylcholine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylethanolamine N-methyltransferase
    NP_011673.1
    • Phosphatidylethanolamine methyltransferase (PEMT); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      802440..805049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181286.1 → NP_011673.1  TPA: phosphatidylethanolamine N-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011673.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5VJA0, D6VUT7, P05374
      UniProtKB/TrEMBL
      G2WEN7, N1P2E1
      Conserved Domains (1) summary
      pfam04191
      Location:471 → 577
      PEMT; Phospholipid methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05374.1

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