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    MTL1 Mtl1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MTL1
    Official Full Name
    Mtl1p
    Primary source
    SGD:S000003255
    Locus tag
    YGR023W
    See related
    AllianceGenome:SGD:S000003255; FungiDB:YGR023W; VEuPathDB:YGR023W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in cellular response to glucose starvation; cellular response to oxidative stress; and fungal-type cell wall organization. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MTL1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (529264..530919)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V1 sector ATPase subunit F Neighboring gene Dpc29p Neighboring gene tRNA-Asp Neighboring gene tRNA guanylyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised. Montella-Manuel S, et al. J Fungi (Basel), 2021 Oct 26. PMID 34829194, Free PMC Article
    2. Toward the discovery of biological functions associated with the mechanosensor Mtl1p of Saccharomyces cerevisiae via integrative multi-OMICs analysis. Martínez-Matías N, et al. Sci Rep, 2021 Apr 1. PMID 33795741, Free PMC Article
    3. Signal flow between CWI/TOR and CWI/RAS in budding yeast under conditions of oxidative stress and glucose starvation. Petkova MI, et al. Commun Integr Biol, 2010 Nov. PMID 21331237, Free PMC Article
    4. Stability control of MTL1 mRNA by the RNA-binding protein Khd1p in yeast. Mauchi N, et al. Cell Struct Funct, 2010. PMID 20953064
    5. Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Rajavel M, et al. Mol Cell Biol, 1999 Jun. PMID 10330137, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mtl1, member of the cell wall integrity pathway of Saccharomyces cerevisiae, plays a positive role in chronological life span (CLS).
      Title: Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival.
    2. Mtl1 O-mannosylation mediated by both Pmt1 and Pmt2 is important for cell survival under oxidative conditions and TOR blockade.
      Title: Mtl1 O-mannosylation mediated by both Pmt1 and Pmt2 is important for cell survival under oxidative conditions and TOR blockade.
    3. results suggest that MTL1 mRNA bears a cis-acting element involved in destabilization by the decapping enzyme and the 5'-3' exonuclease, and Khd1p stabilizes MTL1 mRNA through binding to this element
      Title: Stability control of MTL1 mRNA by the RNA-binding protein Khd1p in yeast.
    4. Mtl1 has an essential role in signaling oxidative stress and quiescence to the CWI pathway and to the general stress response through Rho1 and the inhibition of either the TOR1 or RAS2 functions
      Title: Mtl1 is required to activate general stress response through Tor1 and Ras2 inhibition under conditions of glucose starvation and oxidative stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to glucose starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to glucose starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein catabolic process in the vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mtl1p
    NP_011537.1
    • Transmembrane sensor of the cell wall integrity pathway (CWI); involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; structurally and functionally similar to Mid2p; MTL1 has a paralog, MID2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      529264..530919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181152.1 → NP_011537.1  TPA: Mtl1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011537.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUF7, P53214, Q45U60
      UniProtKB/TrEMBL
      A6ZV12
      Conserved Domains (1) summary
      pfam04478
      Location:315 → 466
      Mid2; Mid2 like cell wall stress sensor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53214.1

    Gene LinkOut

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