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    BFR2 rRNA-processing protein BFR2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BFR2
    Official Full Name
    rRNA-processing protein BFR2
    Primary source
    SGD:S000002707
    Locus tag
    YDR299W
    See related
    AllianceGenome:SGD:S000002707; FungiDB:YDR299W; VEuPathDB:YDR299W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of small-subunit processome. Orthologous to human AATF (apoptosis antagonizing transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BFR2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1059627..1061231)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene sphingosine hydroxylase Neighboring gene F1F0 ATP synthase subunit 5 Neighboring gene glutamate 5-kinase Neighboring gene cleavage/polyadenylation factor CFT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the yeast BFR2 gene is regulated at the transcriptional level and through degradation of its product. Chabane S, et al. Mol Gen Genet, 1998 May. PMID 9645427
    2. Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration. Cheng J, et al. Mol Cell, 2019 Sep 19. PMID 31378463
    3. Over-expression of the yeast BFR2 gene partially suppresses the growth defects induced by Brefeldin A and by four ER-to-Golgi mutations. Chabane S, et al. Curr Genet, 1998 Jan. PMID 9472076
    4. Nucleolar proteins Bfr2 and Enp2 interact with DEAD-box RNA helicase Dbp4 in two different complexes. Soltanieh S, et al. Nucleic Acids Res, 2014 Mar. PMID 24357410, Free PMC Article
    5. Rrp12 and the Exportin Crm1 participate in late assembly events in the nucleolus during 40S ribosomal subunit biogenesis. Moriggi G, et al. PLoS Genet, 2014 Dec. PMID 25474739, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rRNA-processing protein BFR2
    NP_010585.3
    • Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1059627..1061231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180607.3 → NP_010585.3  TPA: rRNA-processing protein BFR2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010585.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSS8, Q06631, Q66RD8
      UniProtKB/TrEMBL
      A6ZYP7, B3LFZ6, C8Z5L1, N1P569
      Conserved Domains (2) summary
      pfam08164
      Location:414 → 498
      TRAUB; Apoptosis-antagonizing transcription factor, C-terminal
      pfam13339
      Location:175 → 300
      AATF-Che1; Apoptosis antagonizing transcription factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06631.1

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