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    REF2 RNA-processing protein REF2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851776, updated on 9-Dec-2024

    Summary

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    Official Symbol
    REF2
    Official Full Name
    RNA-processing protein REF2
    Primary source
    SGD:S000002603
    Locus tag
    YDR195W
    See related
    AllianceGenome:SGD:S000002603; FungiDB:YDR195W; VEuPathDB:YDR195W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity and chromatin binding activity. Involved in RNA metabolic process; positive regulation of mitotic actomyosin contractile ring assembly; and regulation of protein localization to cell division site involved in cytokinesis. Located in cytosol and nucleus. Part of mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See REF2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (848599..850200)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ATP-dependent RNA helicase Neighboring gene uncharacterized protein Neighboring gene putative dephospho-CoA kinase Neighboring gene Cbs2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. REF2 encodes an RNA-binding protein directly involved in yeast mRNA 3'-end formation. Russnak R, et al. Mol Cell Biol, 1995 Mar. PMID 7862160, Free PMC Article
    2. RNA binding analysis of yeast REF2 and its two-hybrid interaction with a new gene product, FIR1. Russnak R, et al. Gene Expr, 1996. PMID 9196079, Free PMC Article
    3. Pti1p and Ref2p found in association with the mRNA 3' end formation complex direct snoRNA maturation. Dheur S, et al. EMBO J, 2003 Jun 2. PMID 12773397, Free PMC Article
    4. Ref2, a regulatory subunit of the yeast protein phosphatase 1, is a novel component of cation homoeostasis. Ferrer-Dalmau J, et al. Biochem J, 2010 Feb 24. PMID 20028335
    5. Coupling between snoRNP assembly and 3' processing controls box C/D snoRNA biosynthesis in yeast. Morlando M, et al. EMBO J, 2004 Jun 16. PMID 15167896, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic actomyosin contractile ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization to cell division site involved in cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sno(s)RNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in termination of RNA polymerase II transcription, poly(A)-coupled IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-processing protein REF2
    NP_010481.3
    • RNA-binding protein; involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes; putative regulatory subunit of type 1 protein phosphatase Glc7p, required for actomyosin ring formation, and for timely dephosphorylation and release of Bnr1p from the division site; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      848599..850200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180503.3 → NP_010481.3  TPA: RNA-processing protein REF2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010481.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSH8, P42073
      UniProtKB/TrEMBL
      B3LG88, C7GN02, C8Z5B0, N1P6J0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42073.2

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