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    PIN3 Pin3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856277, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIN3
    Official Full Name
    Pin3p
    Primary source
    SGD:S000006358
    Locus tag
    YPR154W
    See related
    AllianceGenome:SGD:S000006358; FungiDB:YPR154W; VEuPathDB:YPR154W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LSB2
    Summary
    Involved in negative regulation of Arp2/3 complex-mediated actin nucleation. Located in actin cortical patch. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PIN3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (834565..835212)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Urn1p Neighboring gene May24p Neighboring gene Nca2p Neighboring gene spermine transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress. Chernova TA, et al. Cell Rep, 2017 Jan 17. PMID 28099852, Free PMC Article
    2. Prion-based memory of heat stress in yeast. Chernova TA, et al. Prion, 2017 May 4. PMID 28521568, Free PMC Article
    3. Prions affect the appearance of other prions: the story of [PIN(+)]. Derkatch IL, et al. Cell, 2001 Jul 27. PMID 11511345
    4. Lsb1 is a negative regulator of las17 dependent actin polymerization involved in endocytosis. Spiess M, et al. PLoS One, 2013. PMID 23577202, Free PMC Article
    5. Yeast Rsp5 ubiquitin ligase affects the actin cytoskeleton in vivo and in vitro. Kaminska J, et al. Eur J Cell Biol, 2011 Dec. PMID 22000681

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pin3p
    NP_015480.1
    • Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      834565..835212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184251.1 → NP_015480.1  TPA: Pin3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015480.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4F0, Q06449
      UniProtKB/TrEMBL
      C7GXT9, C8ZJH8, N1NVL9
      Conserved Domains (1) summary
      cl17036
      Location:58 → 110
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06449.1

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