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    SCP1 Scp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854549, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SCP1
    Official Full Name
    Scp1p
    Primary source
    SGD:S000005894
    Locus tag
    YOR367W
    See related
    AllianceGenome:SGD:S000005894; FungiDB:YOR367W; VEuPathDB:YOR367W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables actin filament binding activity and protein-macromolecule adaptor activity. Involved in actin filament organization. Located in actin cortical patch. Orthologous to several human genes including TAGLN2 (transgelin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SCP1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (1026007..1026609)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene oleate-activated transcription factor PIP2 Neighboring gene putative flavin adenine dinucleotide transporter Neighboring gene Rad17p Neighboring gene ribosomal 40S subunit protein S12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for cross-linking proteins in actin filament network organization and force generation. Hill JM, et al. Proc Natl Acad Sci U S A, 2024 Oct 22. PMID 39405356,
    2. A role for the actin cytoskeleton in cell death and aging in yeast. Gourlay CW, et al. J Cell Biol, 2004 Mar 15. PMID 15024029, Free PMC Article
    3. SCP1 encodes an actin-bundling protein in yeast. Winder SJ, et al. Biochem J, 2003 Oct 15. PMID 12868959, Free PMC Article
    4. The Saccharomyces cerevisiae calponin/transgelin homolog Scp1 functions with fimbrin to regulate stability and organization of the actin cytoskeleton. Goodman A, et al. Mol Biol Cell, 2003 Jul. PMID 12857851, Free PMC Article
    5. Interactions between the yeast SM22 homologue Scp1 and actin demonstrate the importance of actin bundling in endocytosis. Gheorghe DM, et al. J Biol Chem, 2008 May 30. PMID 18400761, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interactions between the yeast SM22 homologue Scp1 and actin demonstrate the importance of actin bundling in endocytosis
      Title: Interactions between the yeast SM22 homologue Scp1 and actin demonstrate the importance of actin bundling in endocytosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Scp1p
    NP_015012.3
    • Component of yeast cortical actin cytoskeleton; binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      1026007..1026609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183787.3 → NP_015012.3  TPA: Scp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015012.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W360, Q08873
      UniProtKB/TrEMBL
      A6ZPJ5, B3LK22, C7GNQ3, G2WNM6, N1P3X0
      Conserved Domains (1) summary
      COG5199
      Location:15 → 200
      SCP1; Calponin [Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08873.1

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