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    ZRG17 Zn(2+) transporter ZRG17 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZRG17
    Official Full Name
    Zn(2+) transporter ZRG17
    Primary source
    SGD:S000005322
    Locus tag
    YNR039C
    See related
    AllianceGenome:SGD:S000005322; FungiDB:YNR039C; VEuPathDB:YNR039C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables zinc ion transmembrane transporter activity. Involved in zinc ion transport. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZRG17 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (697614..699431, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein RSM19 Neighboring gene putative ATP-dependent RNA helicase DBP6 Neighboring gene Mrx15p Neighboring gene 4-hydroxybenzoate octaprenyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional regulation of the Zrg17 zinc transporter of the yeast secretory pathway. Wu YH, et al. Biochem J, 2011 Apr 1. PMID 21250939, Free PMC Article
    2. Zinc depletion activates the endoplasmic reticulum-stress sensor Ire1 via pleiotropic mechanisms. Nguyen TS, et al. Biosci Biotechnol Biochem, 2013. PMID 23748779
    3. Heteromeric protein complexes mediate zinc transport into the secretory pathway of eukaryotic cells. Ellis CD, et al. J Biol Chem, 2005 Aug 5. PMID 15961382
    4. Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast. Lyons TJ, et al. Proc Natl Acad Sci U S A, 2000 Jul 5. PMID 10884426, Free PMC Article
    5. Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging. Yuan DS. Genetics, 2000 Sep. PMID 10978274, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in zinc ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in zinc ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zn(2+) transporter ZRG17
    NP_014437.1
    • Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      697614..699431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183216.1 → NP_014437.1  TPA: Zn(2+) transporter ZRG17 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014437.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1L5, E9P919, P53735
      UniProtKB/TrEMBL
      C7GLL7, G2WL97, N1NZS3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53735.1

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