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    ORA1 oxidoreductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855266, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ORA1
    Official Full Name
    oxidoreductase
    Primary source
    SGD:S000004839
    Locus tag
    YMR226C
    See related
    AllianceGenome:SGD:S000004839; FungiDB:YMR226C; VEuPathDB:YMR226C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables carbonyl reductase (NADPH) activity; diacetyl reductase ((S)-acetoin forming) (NAD+) activity; and serine 3-dehydrogenase activity. Involved in acetoin metabolic process. Located in nucleus. Is active in cytoplasm. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ORA1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (721593..722396, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene MRX complex nuclease subunit Neighboring gene mitochondrial 54S ribosomal protein YmL44 Neighboring gene TATA-binding protein-associated factor TAF7 Neighboring gene RNA polymerase specificity factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Asymmetric synthesis of both antipodes of beta-hydroxy nitriles and beta-hydroxy carboxylic acids via enzymatic reduction or sequential reduction/hydrolysis. Ankati H, et al. J Org Chem, 2009 Feb 20. PMID 19161324
    2. Characterization of short-chain dehydrogenase/reductase homologues of Escherichia coli (YdfG) and Saccharomyces cerevisiae (YMR226C). Fujisawa H, et al. Biochim Biophys Acta, 2003 Jan 31. PMID 12535615
    3. Reaction and strain engineering for improved stereo-selective whole-cell reduction of a bicyclic diketone. Johanson T, et al. Appl Microbiol Biotechnol, 2008 Jan. PMID 17962934
    4. Synthesis of optically pure 2-azido-1-arylethanols with isolated enzymes and conversion to triazole-containing beta-blocker analogues employing click chemistry. Ankati H, et al. J Org Chem, 2008 Aug 15. PMID 18630881
    5. 1-Acyldihydroxyacetone-phosphate reductase (Ayr1p) of the yeast Saccharomyces cerevisiae encoded by the open reading frame YIL124w is a major component of lipid particles. Athenstaedt K, et al. J Biol Chem, 2000 Jan 7. PMID 10617610

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carbonyl reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diacetyl reductase ((S)-acetoin forming) (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine 3-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetoin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oxidoreductase
    NP_013953.1
    • NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; catalyzes the reduction of (S)-alpha-acetolactate to 2,3-dimethylglycerate; short-chain dehydrogenase/reductase (SDR) family member; GFP fusion protein localizes to the cytoplasm and nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      721593..722396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182733.1 → NP_013953.1  TPA: oxidoreductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013953.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W051, Q05016
      UniProtKB/TrEMBL
      A6ZMT8, B3LMB4, B5VPZ4, C7GRC5, C8ZF90, G2WKT3, N1P5V4
      Conserved Domains (1) summary
      cd05346
      Location:14 → 266
      SDR_c5; classical (c) SDR, subgroup 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05016.1

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