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    MME1 Mme1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855202, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MME1
    Official Full Name
    Mme1p
    Primary source
    SGD:S000004776
    Locus tag
    YMR166C
    See related
    AllianceGenome:SGD:S000004776; FungiDB:YMR166C; VEuPathDB:YMR166C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables magnesium ion transmembrane transporter activity. Involved in magnesium ion export from mitochondrion. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MME1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (593367..594473, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Mss11p Neighboring gene phosphatidate phosphatase PAH1 Neighboring gene mismatch repair ATPase MLH1 Neighboring gene Cep3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel mitochondrial carrier protein Mme1 acts as a yeast mitochondrial magnesium exporter. Cui Y, et al. Biochim Biophys Acta, 2015 Mar. PMID 25585246
    2. The yeast mitochondrial transport proteins: new sequences and consensus residues, lack of direct relation between consensus residues and transmembrane helices, expression patterns of the transport protein genes, and protein-protein interactions with other proteins. Belenkiy R, et al. Biochim Biophys Acta, 2000 Jul 31. PMID 10930523
    3. Mechanistic insights on the mode of action of an antiproliferative thiosemicarbazone-nickel complex revealed by an integrated chemogenomic profiling study. Baruffini E, et al. Sci Rep, 2020 Jun 29. PMID 32601343, Free PMC Article
    4. Complex mutation profiles in mismatch repair and ribonucleotide reductase mutants reveal novel repair substrate specificity of MutS homolog (MSH) complexes. Lamb NA, et al. Genetics, 2022 Jul 30. PMID 35686905, Free PMC Article
    5. Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis. Mattiazzi Ušaj M, et al. Metallomics, 2015 Sep. PMID 26067383

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in magnesium ion export from mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in magnesium ion export from mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in magnesium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mme1p
    NP_013889.1
    • Transporter of the mitochondrial inner membrane that exports magnesium; involved in mitochondrial Mg2+ homeostasis; has similarity to human mitochondrial ATP-Mg/Pi carriers

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      593367..594473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182670.1 → NP_013889.1  TPA: Mme1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013889.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZY8, Q03829
      UniProtKB/TrEMBL
      A6ZMM5, B3LM54, B5VPT7, C7GU56, C8ZF26, N1NXG5
      Conserved Domains (2) summary
      PTZ00168
      Location:55 → 283
      PTZ00168; mitochondrial carrier protein; Provisional
      pfam00153
      Location:51 → 142
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03829.1

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