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    CAR2 ornithine-oxo-acid transaminase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851158, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CAR2
    Official Full Name
    ornithine-oxo-acid transaminase
    Primary source
    SGD:S000004430
    Locus tag
    YLR438W
    See related
    AllianceGenome:SGD:S000004430; FungiDB:YLR438W; VEuPathDB:YLR438W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ornithine aminotransferase activity. Involved in ornithine metabolic process. Located in cytosol. Used to study gyrate atrophy. Human ortholog(s) of this gene implicated in gyrate atrophy. Orthologous to human OAT (ornithine aminotransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CAR2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1012501..1013775)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ecm30p Neighboring gene Dif1p Neighboring gene U4/U6-U5 snRNP complex subunit LSM3 Neighboring gene mitochondrial 54S ribosomal protein YmL4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. THE PATHWAY OF ARGININE BREAKDOWN IN SACCHAROMYCES CEREVISIAE. MIDDELHOVEN WJ. Biochim Biophys Acta, 1964 Dec 9. PMID 14263163
    2. Functional analysis of the regulatory region adjacent to the cargB gene of Saccharomyces cerevisiae. Nucleotide sequence, gene fusion experiments and cis-dominant regulatory mutation analysis. Degols G. Eur J Biochem, 1987 Nov 16. PMID 2824201
    3. Expression and processing of human ornithine-delta-aminotransferase in Saccharomyces cerevisiae. Dougherty KM, et al. Hum Mol Genet, 1993 Nov. PMID 8281144
    4. Molecular characterization of transposable-element-associated mutations that lead to constitutive L-ornithine aminotransferase expression in Saccharomyces cerevisiae. Degols G, et al. Eur J Biochem, 1987 Jun 1. PMID 3036506
    5. Mating-type effect on cis mutations leading to constitutivity of ornithine transaminase in diploid cells of Saccharomyces cerevisiae. Deschamps J, et al. Genetics, 1979 Jul. PMID 395019, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ornithine aminotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ornithine aminotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ornithine aminotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginine catabolic process to glutamate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arginine catabolic process to proline via ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ornithine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    ornithine-oxo-acid transaminase
    NP_013542.1
    • L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1012501..1013775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182326.1 → NP_013542.1  TPA: ornithine-oxo-acid transaminase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013542.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ72, P07991
      UniProtKB/TrEMBL
      A7A1V7, B3RHU6, C7GSL8, C8ZE45, G2WJP8, N1NZX6
      Conserved Domains (1) summary
      TIGR01885
      Location:8 → 422
      Orn_aminotrans; ornithine aminotransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07991.2

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