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    ELO3 fatty acid elongase ELO3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851087, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ELO3
    Official Full Name
    fatty acid elongase ELO3
    Primary source
    SGD:S000004364
    Locus tag
    YLR372W
    See related
    AllianceGenome:SGD:S000004364; FungiDB:YLR372W; VEuPathDB:YLR372W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    APA1; SRE1; SUR4; VBM1
    Summary
    Enables fatty acid elongase activity. Involved in late endosome to vacuole transport via multivesicular body sorting pathway; lipid biosynthetic process; and post-Golgi vesicle-mediated transport. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in corneal dystrophy; spinocerebellar ataxia type 34; and spinocerebellar ataxia type 38. Orthologous to several human genes including ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL4 (ELOVL fatty acid elongase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ELO3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (867354..868391)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Arc18p Neighboring gene Rho family guanine nucleotide exchange factor ROM2 Neighboring gene Vid22p Neighboring gene Stp3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional control of yeast plasma membrane H(+)-ATPase by glucose. Cloning and characterization of a new gene involved in this regulation. García-Arranz M, et al. J Biol Chem, 1994 Jul 8. PMID 8027068
    2. The RAD3 gene of Saccharomyces cerevisiae: isolation and characterization of a temperature-sensitive mutant in the essential function and of extragenic suppressors of this mutant. Naumovski L, et al. Mol Gen Genet, 1987 Oct. PMID 3323825
    3. Functional analysis of very long-chain fatty acid elongase gene, HpELO2, in the methylotrophic yeast Hansenula polymorpha. Prasitchoke P, et al. Appl Microbiol Biotechnol, 2007 Aug. PMID 17520249
    4. Members of the Arabidopsis FAE1-like 3-ketoacyl-CoA synthase gene family substitute for the Elop proteins of Saccharomyces cerevisiae. Paul S, et al. J Biol Chem, 2006 Apr 7. PMID 16449229
    5. Sphingolipid biosynthetic pathway genes FEN1 and SUR4 modulate amphotericin B resistance. Sharma S, et al. Antimicrob Agents Chemother, 2014. PMID 24395234, Free PMC Article

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELO3 and YKU70/80 share a common pathway for the regulation of telomere length
      Title: Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function.
    2. SUR4 does not remediate the steady-state actin cytoskeletal defects of rvs167 or rvs161 cells
      Title: Characterizing the sphingolipid signaling pathway that remediates defects associated with loss of the yeast amphiphysin-like orthologs, Rvs161p and Rvs167p.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid elongase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid elongase ELO3
    NP_013476.3
    • Elongase; involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      867354..868391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182261.3 → NP_013476.3  TPA: fatty acid elongase ELO3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013476.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ09, P40319
      UniProtKB/TrEMBL
      A7A1P9, B3RHN9, B5VNR0, C7GRW5, G2WJI9, N1P1R1
      Conserved Domains (1) summary
      pfam01151
      Location:88 → 307
      ELO; GNS1/SUR4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40319.1

    Gene LinkOut

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