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    Arl4a ADP-ribosylation factor-like 4A [ Mus musculus (house mouse) ]

    Gene ID: 11861, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Arl4aprovided by MGI
    Official Full Name
    ADP-ribosylation factor-like 4Aprovided by MGI
    Primary source
    MGI:MGI:99437
    See related
    Ensembl:ENSMUSG00000047446 AllianceGenome:MGI:99437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arl4
    Summary
    Predicted to enable GTP binding activity. Acts upstream of or within brown fat cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; jaw bone; paraxial mesenchyme; skeletal musculature; and testis. Orthologous to human ARL4A (ARF like GTPase 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 30.0), liver E14 (RPKM 10.1) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arl4a in Genome Data Viewer
    Location:
    12 B1; 12 18.06 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (40083290..40087986, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (40033291..40037987, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40399 Neighboring gene ubiquitin specific peptidase 9, X chromosome pseudogene Neighboring gene STARR-seq mESC enhancer starr_31951 Neighboring gene predicted gene, 53717 Neighboring gene STARR-positive B cell enhancer mm9_chr12:40763838-40764139 Neighboring gene STARR-positive B cell enhancer ABC_E7130 Neighboring gene ADP-ribosylation factor-like 4A, opposite strand Neighboring gene scinderin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endosomal Arl4A attenuates EGFR degradation by binding to the ESCRT-II component VPS36. Lin SJ, et al. Nat Commun, 2023 Nov 29. PMID 38030597, Free PMC Article
    2. Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene. Schürmann A, et al. Mol Cell Biol, 2002 Apr. PMID 11909968, Free PMC Article
    3. The mouse ADP-ribosylation factor-like 4 gene: two separate promoters direct specific transcription in tissues and testicular germ cell. Jacobs S, et al. Biochem J, 1998 Oct 15. PMID 9761722, Free PMC Article
    4. ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. Lin CY, et al. J Biol Chem, 2000 Dec 1. PMID 10980193
    5. Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. Schürmann A, et al. J Biol Chem, 1994 Jun 3. PMID 8195219

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene.
      Title: Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene.
    2. This gene was a target of WNT signlaing in the dorsal somite.
      Title: Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 4A
    Names
    ADP-ribosylation factor-like 4
    ADP-ribosylation-like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039515.1 → NP_001034604.1  ADP-ribosylation factor-like protein 4A

      See identical proteins and their annotated locations for NP_001034604.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131921, AK048606, CJ164717
      Consensus CDS
      CCDS25890.1
      UniProtKB/Swiss-Prot
      P41275, P61213, Q3TGR5
      Related
      ENSMUSP00000099013.4, ENSMUST00000101472.4
      Conserved Domains (1) summary
      cd04152
      Location:18 → 200
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    2. NM_007487.3 → NP_031513.1  ADP-ribosylation factor-like protein 4A

      See identical proteins and their annotated locations for NP_031513.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AC131921, AK048606
      Consensus CDS
      CCDS25890.1
      UniProtKB/Swiss-Prot
      P41275, P61213, Q3TGR5
      Related
      ENSMUSP00000114458.2, ENSMUST00000146905.2
      Conserved Domains (1) summary
      cd04152
      Location:18 → 200
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      40083290..40087986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61213.1 GenPept UniProtKB/Swiss-Prot:P61213

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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