GCD14 tRNA 1-methyladenosine methyltransferase subunit GCD14 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GCD14
Official Full Name: tRNA 1-methyladenosine methyltransferase subunit GCD14
Primary source: SGD:S000003661
Locus tag: YJL125C
See related: AllianceGenome:SGD:S000003661; FungiDB:YJL125C; VEuPathDB:YJL125C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TRM61
Summary: Contributes to tRNA (adenine(58)-N1)-methyltransferase activity. Involved in tRNA methylation. Located in nucleus. Part of tRNA (m1A) methyltransferase complex. Orthologous to human TRMT61A (tRNA methyltransferase 61A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GCD14 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (185528..186679, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 has been reported.
Title: Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae.
X-ray diffraction analysis of the TRM6-TRM61 complex were performed in this study. The crystals diffracted to 2.80 A resolution and belonged to the trigonal space group P3(1)21 or P3(2)21, with unit-cell parameters a = b = 139.14, c = 101.62 A
Title: Crystallization and preliminary X-ray diffraction crystallographic study of tRNA m(1)A58 methyltransferase from Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to tRNA (adenine(58)-N1)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA (adenine(58)-N1)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to tRNA (adenine(58)-N1)-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of tRNA (m1A) methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of tRNA (m1A) methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of tRNA (m1A) methyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of tRNA (m1A) methyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: tRNA 1-methyladenosine methyltransferase subunit GCD14

NP_012410.1

EC 2.1.1.220

Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

185528..186679 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181558.1 → NP_012410.1 TPA: tRNA 1-methyladenosine methyltransferase subunit GCD14 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012410.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VW61, P46959

UniProtKB/TrEMBL

G2WGP8, N1P1K0

Conserved Domains (1) summary

COG2519
Location:12 → 291

Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]