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    putative helicase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851137, updated on 27-Dec-2024

    Summary

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    Official Full Name
    putative helicase
    Primary source
    SGD:S000004411
    Locus tag
    YLR419W
    See related
    AllianceGenome:SGD:S000004411; FungiDB:YLR419W; VEuPathDB:YLR419W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Predicted to be involved in chromatin looping and chromatin remodeling. Located in mitochondrion. Orthologous to several human genes including DHX57 (DExH-box helicase 57). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (958428..962735)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ESCRT-II subunit protein VPS36 Neighboring gene Cdc73p Neighboring gene tRNA-Leu Neighboring gene dihydroorotase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary history of the retinoblastoma gene from archaea to eukarya. Takemura M. Biosystems, 2005 Dec. PMID 16181730
    2. Dhr1p, a putative DEAH-box RNA helicase, is associated with the box C+D snoRNP U3. Colley A, et al. Mol Cell Biol, 2000 Oct. PMID 10982841, Free PMC Article
    3. Systematic identification, classification, and characterization of the open reading frames which encode novel helicase-related proteins in Saccharomyces cerevisiae by gene disruption and Northern analysis. Shiratori A, et al. Yeast, 1999 Feb. PMID 10077188
    4. Parallel analysis of genetic selections using whole genome oligonucleotide arrays. Cho RJ, et al. Proc Natl Acad Sci U S A, 1998 Mar 31. PMID 9520439, Free PMC Article
    5. Mass spectrometric identification of proteins that interact through specific domains of the poly(A) binding protein. Richardson R, et al. Mol Genet Genomics, 2012 Sep. PMID 22836166, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    putative helicase
    NP_013523.3
    • Predicted RNA helicase of the DEAH-box family; the authentic, non-tagged protein is detected in highly purified mitochondria in HTP studies and sediments with the 40S ribosomal subunit; crosslinks with 18S rRNA; non-essential gene; contains a ubiquitin-associated domain, an RWD domain, a helicase ATP-binding DEAD-like domain, a helicase C terminal domain and a helicase associated domain; does not contain a Rb-like A/B pocket structure; homolog of mammalian translation initiation factor DHX29

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      958428..962735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182307.3 → NP_013523.3  TPA: putative helicase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013523.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ55, Q06698
      UniProtKB/TrEMBL
      G2WJN1
      Conserved Domains (3) summary
      COG1643
      Location:563 → 1428
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14271
      Location:369 → 409
      UBA_YLR419W_like; UBA domain found in Saccharomyces cerevisiae putative ATP-dependent RNA helicase YLR419W and similar proteins
      pfam05773
      Location:426 → 528
      RWD; RWD domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06698.1

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