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    TMEM144 transmembrane protein 144 [ Homo sapiens (human) ]

    Gene ID: 55314, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TMEM144provided by HGNC
    Official Full Name
    transmembrane protein 144provided by HGNC
    Primary source
    HGNC:HGNC:25633
    See related
    Ensembl:ENSG00000164124 MIM:620325; AllianceGenome:HGNC:25633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLC35G7
    Summary
    Predicted to enable carbohydrate transmembrane transporter activity. Predicted to be involved in carbohydrate transmembrane transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 40.3), duodenum (RPKM 10.7) and 13 other tissues See more
    Orthologs
    mouse all
    NEW
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    Genomic context

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    See TMEM144 in Genome Data Viewer
    Location:
    4q32.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (158210486..158255416)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (161562668..161607571)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (159131638..159176568)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928007 Neighboring gene GASK1B antisense RNA 1 Neighboring gene NUDT19 pseudogene 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159131026-159131580 Neighboring gene Sharpr-MPRA regulatory region 4077 Neighboring gene NANOG hESC enhancer GRCh37_chr4:159166017-159166518 Neighboring gene NANOG hESC enhancer GRCh37_chr4:159195233-159195734 Neighboring gene AIDA pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 15052 Neighboring gene uncharacterized LOC105377510

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent. Prentice LM, et al. BMC Genomics, 2011 Apr 28. PMID 21527035, Free PMC Article
    2. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article
    3. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
    4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11155

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 144

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018342.5 → NP_060812.2  transmembrane protein 144

      See identical proteins and their annotated locations for NP_060812.2

      Status: VALIDATED

      Source sequence(s)
      AC098679, BC054487
      Consensus CDS
      CCDS3799.1
      UniProtKB/Swiss-Prot
      D3DP24, Q49A05, Q7Z5S9, Q9NUT3
      Related
      ENSP00000296529.6, ENST00000296529.11
      Conserved Domains (1) summary
      pfam07857
      Location:9 → 344
      TMEM144; Transmembrane family, TMEM144 of transporters

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      158210486..158255416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263110.3 → XP_005263167.1  transmembrane protein 144 isoform X1

      See identical proteins and their annotated locations for XP_005263167.1

      UniProtKB/Swiss-Prot
      D3DP24, Q49A05, Q7Z5S9, Q9NUT3
      Conserved Domains (1) summary
      pfam07857
      Location:9 → 344
      TMEM144; Transmembrane family, TMEM144 of transporters

    2. XM_017008366.2 → XP_016863855.1  transmembrane protein 144 isoform X1

      UniProtKB/Swiss-Prot
      D3DP24, Q49A05, Q7Z5S9, Q9NUT3
      Conserved Domains (1) summary
      pfam07857
      Location:9 → 344
      TMEM144; Transmembrane family, TMEM144 of transporters

    3. XM_047415908.1 → XP_047271864.1  transmembrane protein 144 isoform X2

      UniProtKB/TrEMBL
      D6RCA2, D6RDI4
      Related
      ENSP00000420930.1, ENST00000511532.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      161562668..161607571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z5S9.1 GenPept UniProtKB/Swiss-Prot:Q7Z5S9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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