LGALS4 galectin 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LGALS4provided by HGNC
Official Full Name: galectin 4provided by HGNC
Primary source: HGNC:HGNC:6565
See related: Ensembl:ENSG00000171747 MIM:602518; AllianceGenome:HGNC:6565
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GAL4; L36LBP
Summary: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]
Expression: Biased expression in colon (RPKM 740.5), duodenum (RPKM 465.8) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (38801674..38812945, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (41605720..41616989, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (39292314..39303585, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High expression of B3GALT5 suppresses the galectin-4-mediated peritoneal dissemination of poorly differentiated gastric cancer cells.
Title: High expression of B3GALT5 suppresses the galectin-4-mediated peritoneal dissemination of poorly differentiated gastric cancer cells.
Galectin-4 Is Involved in the Structural Changes of Glycosphingolipid Glycans in Poorly Differentiated Gastric Cancer Cells with High Metastatic Potential.
Title: Galectin-4 Is Involved in the Structural Changes of Glycosphingolipid Glycans in Poorly Differentiated Gastric Cancer Cells with High Metastatic Potential.
Multifaceted role of galectin-4 in cancer: A systematic review.
Title: Multifaceted role of galectin-4 in cancer: A systematic review.
Suppression of galectin-4 attenuates peritoneal metastasis of poorly differentiated gastric cancer cells.
Title: Suppression of galectin-4 attenuates peritoneal metastasis of poorly differentiated gastric cancer cells.
Enhancement of Vivid-based photo-activatable Gal4 transcription factor in mammalian cells.
Title: Enhancement of Vivid-based photo-activatable Gal4 transcription factor in mammalian cells.
Galectin-4 levels in hospitalized versus non-hospitalized subjects with obesity: the Malmo Preventive Project.
Title: Galectin-4 levels in hospitalized versus non-hospitalized subjects with obesity: the Malmö Preventive Project.
Overexpression of galectin-4 in placentas of women with gestational diabetes.
Title: Overexpression of galectin-4 in placentas of women with gestational diabetes.
Galectin-4 as a Novel Biomarker of Neonatal Intestinal Injury.
Title: Galectin-4 as a Novel Biomarker of Neonatal Intestinal Injury.
Galectin network in osteoarthritis: galectin-4 programs a pathogenic signature of gene and effector expression in human chondrocytes in vitro.
Title: Galectin network in osteoarthritis: galectin-4 programs a pathogenic signature of gene and effector expression in human chondrocytes in vitro.
SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role.
Title: SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

RH36905 (e-PCR)
- UniSTS:87932

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables galactoside binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antibacterial peptide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: galectin-4

Names: L-36 lactose-binding protein; antigen NY-CO-27; gal-4; lactose-binding lectin 4; lectin, galactoside-binding, soluble, 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006149.4 → NP_006140.1 galectin-4

See identical proteins and their annotated locations for NP_006140.1

Status: REVIEWED

Source sequence(s)

AA130458, AK290269

Consensus CDS

CCDS12521.1

UniProtKB/Swiss-Prot

P56470

UniProtKB/TrEMBL

Q6FHZ4

Related

ENSP00000302100.3, ENST00000307751.9

Conserved Domains (2) summary

smart00908
Location:199 → 322

Gal-bind_lectin; Galactoside-binding lectin

cd00070
Location:18 → 147

GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

38801674..38812945 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011526973.3 → XP_011525275.1 galectin-4 isoform X1

Conserved Domains (2) summary

smart00908
Location:186 → 309

Gal-bind_lectin; Galactoside-binding lectin

cd00070
Location:18 → 147

GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...