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    SOCS7 suppressor of cytokine signaling 7 [ Homo sapiens (human) ]

    Gene ID: 30837, updated on 10-Dec-2024

    Summary

    Official Symbol
    SOCS7provided by HGNC
    Official Full Name
    suppressor of cytokine signaling 7provided by HGNC
    Primary source
    HGNC:HGNC:29846
    See related
    Ensembl:ENSG00000274211 MIM:608788; AllianceGenome:HGNC:29846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NAP4; NCKAP4
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity; phosphorylation-dependent protein binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of neuron migration. Predicted to act upstream of or within several processes, including brain development; fat cell differentiation; and insulin receptor signaling pathway. Located in cytosol. Is active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 18.1), brain (RPKM 7.5) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SOCS7 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38351844..38405593)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (39214750..39268637)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36507727..36561846)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36488638-36489138 Neighboring gene NANOG hESC enhancer GRCh37_chr17:36497214-36497738 Neighboring gene G protein-coupled receptor 179 Neighboring gene uncharacterized LOC124903991 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36570079-36571013 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:36571014-36571949 and GRCh37_chr17:36571950-36572884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36574173-36574722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36574723-36575272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36575776-36576704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36577634-36578562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36580149-36580794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36584872-36585780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36585781-36586688 Neighboring gene Rho GTPase activating protein 23 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36592213-36592713 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36597014-36597516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36605280-36606221 Neighboring gene uncharacterized LOC101929494 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36607163-36608104 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:36614287-36614452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36616590-36617218 Neighboring gene Sharpr-MPRA regulatory region 7659 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36621073-36621864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36625516-36626152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36628374-36628874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36640731-36641252 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36649489-36649990 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36649991-36650490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36655308-36655834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36655835-36656359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36665002-36665819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36665820-36666636 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:36706969-36707178 Neighboring gene SRC kinase signaling inhibitor 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36717306-36717859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36718413-36718965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36718966-36719517 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36719518-36720070 Neighboring gene uncharacterized LOC105371761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36720624-36721176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36721177-36721728

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables phosphorylation-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within layer formation in cerebral cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    suppressor of cytokine signaling 7
    Names
    NAP-4
    NCK-associated protein 4
    Nck, Ash and phospholipase C binding protein
    SOCS-7
    nck, Ash and phospholipase C gamma-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014598.4NP_055413.2  suppressor of cytokine signaling 7

      Status: VALIDATED

      Source sequence(s)
      AB005216, AC244092, AC244153, BC128607
      Consensus CDS
      CCDS32637.2
      UniProtKB/Swiss-Prot
      A2VCU2, O14512, Q0IJ63
      UniProtKB/TrEMBL
      A0A5F9YLF9
      Related
      ENSP00000482229.2, ENST00000612932.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      38351844..38405593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024551.2XP_016880040.1  suppressor of cytokine signaling 7 isoform X1

      UniProtKB/TrEMBL
      A0A087X1Q5
      Related
      ENSP00000484381.2, ENST00000613678.5
    2. XM_017024552.2XP_016880041.1  suppressor of cytokine signaling 7 isoform X2

      UniProtKB/TrEMBL
      A0A087X1Q5

    RNA

    1. XR_007065295.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      2386792..2440912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329283.1XP_054185258.1  suppressor of cytokine signaling 7 isoform X1

      UniProtKB/TrEMBL
      A0A087X1Q5
    2. XM_054329284.1XP_054185259.1  suppressor of cytokine signaling 7 isoform X2

      UniProtKB/TrEMBL
      A0A087X1Q5

    RNA

    1. XR_008485631.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      39214750..39268637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315892.1XP_054171867.1  suppressor of cytokine signaling 7 isoform X1

      UniProtKB/TrEMBL
      A0A087X1Q5
    2. XM_054315893.1XP_054171868.1  suppressor of cytokine signaling 7 isoform X2

      UniProtKB/TrEMBL
      A0A087X1Q5

    RNA

    1. XR_008484813.1 RNA Sequence