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    PPFIA2 PTPRF interacting protein alpha 2 [ Homo sapiens (human) ]

    Gene ID: 8499, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PPFIA2provided by HGNC
    Official Full Name
    PTPRF interacting protein alpha 2provided by HGNC
    Primary source
    HGNC:HGNC:9246
    See related
    Ensembl:ENSG00000139220 MIM:603143; AllianceGenome:HGNC:9246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mammals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Biased expression in brain (RPKM 7.4), adrenal (RPKM 1.4) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See PPFIA2 in Genome Data Viewer
    Location:
    12q21.31
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (81257975..81759350, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (81236956..81738412, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (81651754..82153129, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984535 Neighboring gene NANOG hESC enhancer GRCh37_chr12:81489283-81489784 Neighboring gene acyl-CoA synthetase short chain family member 3 Neighboring gene NANOG hESC enhancer GRCh37_chr12:81602215-81602716 Neighboring gene microRNA 4699 Neighboring gene PPFIA2 antisense RNA 1 Neighboring gene uncharacterized LOC105369872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:82005227-82005726 Neighboring gene NANOG hESC enhancer GRCh37_chr12:82087706-82088318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:82151989-82152927 Neighboring gene vomeronasal 1 receptor 57 pseudogene Neighboring gene long intergenic non-protein coding RNA 2426

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Liprin-alpha2 gene, protein tyrosine phosphatase LAR interacting protein related gene, is downregulated by androgens in the human prostate cancer cell line LNCaP. Fujinami K, et al. Int J Mol Med, 2002 Aug. PMID 12119554
    2. Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function. He Y, et al. Eur Neuropsychopharmacol, 2019 May. PMID 30879928
    3. SNP array screening of cryptic genomic imbalances in 450 Japanese subjects with intellectual disability and multiple congenital anomalies previously negative for large rearrangements. Uehara DT, et al. J Hum Genet, 2016 Apr. PMID 26740234
    4. Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures. Wei Z, et al. Mol Cell, 2011 Aug 19. PMID 21855798
    5. Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2. Hawthorne F, et al. Invest Ophthalmol Vis Sci, 2013 Mar 21. PMID 23422819, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function.
      Title: Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function.
    2. mong the 22 cases, we identified PPFIA2 as a novel candidate gene forIntellect Analysis of copy-neutral loss of heterozygosity (CNLOH) detected one case in which the CNLOH regions seem to be significant. The SNP array detected a modest fraction of small causative CNVs, which is explained by the fact that the majority of causative CNVs have larger sizes, and those had been mostly identified in the two previous screenings.
      Title: SNP array screening of cryptic genomic imbalances in 450 Japanese subjects with intellectual disability and multiple congenital anomalies previously negative for large rearrangements.
    3. 3 genes identified by association study and supported by ocular expression and/or replication, UHRF1BP1L, PTPRR, and PPFIA2, are novel candidates for myopic development within the MYP3 locus that should be further studied.
      Title: Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2.
    4. Liprins can mediate assembly of target proteins into large protein complexes capable of regulating numerous cellular activities.
      Title: Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. Liprin-alpha2 expression is downregulated by androgens in prostate cancer cells. It might play a role in androgen-responsive human prostate cancer & the loss of this gene expression might be associated with the androgen-independence.
      Title: Liprin-alpha2 gene, protein tyrosine phosphatase LAR interacting protein related gene, is downregulated by androgens in the human prostate cancer cell line LNCaP.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog
    Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association study of multiplex schizophrenia pedigrees.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 (PPFIA2) is important for HIV-1 replication PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41378, MGC132572

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in dense core granule cytoskeletal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of postsynaptic density structure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in presynapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic active zone TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    liprin-alpha-2
    Names
    protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001220473.3 → NP_001207402.1  liprin-alpha-2 isoform b

      See identical proteins and their annotated locations for NP_001207402.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the UTRs and coding region, compared to variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AB210009, AW304872, BM661844
      Consensus CDS
      CCDS59236.1
      UniProtKB/TrEMBL
      G3V200, Q4LE62
      Related
      ENSP00000449558.2, ENST00000550584.6
      Conserved Domains (4) summary
      cd09562
      Location:895 → 965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1019 → 1084
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1104 → 1175
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:201 → 533
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001220474.3 → NP_001207403.1  liprin-alpha-2 isoform c

      See identical proteins and their annotated locations for NP_001207403.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the UTRs and coding region, compared to variant 1. It encodes isoform c, which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AB210009, AK126971, AW304872, BQ027545, CB051855, DA329958, EL947964
      Consensus CDS
      CCDS55854.1
      UniProtKB/TrEMBL
      Q4LE62
      Related
      ENSP00000450298.1, ENST00000549325.5
      Conserved Domains (5) summary
      cd09562
      Location:880 → 950
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1004 → 1069
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1089 → 1160
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:183 → 515
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05622
      Location:41 → 272
      HOOK; HOOK protein

    3. NM_001220475.2 → NP_001207404.1  liprin-alpha-2 isoform d

      See identical proteins and their annotated locations for NP_001207404.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform d, which is shorter than isoform a.
      Source sequence(s)
      AB210009, AW304872, BC104912, BM661844, CB051855, EL947964
      Consensus CDS
      CCDS55855.1
      UniProtKB/TrEMBL
      Q4LE62
      Conserved Domains (4) summary
      cd09562
      Location:895 → 965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:998 → 1063
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1083 → 1154
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:201 → 533
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_001220476.2 → NP_001207405.1  liprin-alpha-2 isoform e

      See identical proteins and their annotated locations for NP_001207405.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform e, which is shorter than isoform a.
      Source sequence(s)
      AB210009, AW304872, BC143485, BM661844, CB051855, EL947964
      Consensus CDS
      CCDS55856.1
      UniProtKB/TrEMBL
      Q4LE62
      Conserved Domains (4) summary
      cd09562
      Location:895 → 965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1013 → 1078
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1098 → 1169
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:201 → 533
      SMC_N; RecF/RecN/SMC N terminal domain

    5. NM_001220477.2 → NP_001207406.1  liprin-alpha-2 isoform f

      See identical proteins and their annotated locations for NP_001207406.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences in the 5' UTR and coding region, compared to variant 1. It encodes isoform f, which is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK299853, AL713132, AW304872, BM661844, CB051855, DA329958, EL947964
      Consensus CDS
      CCDS55853.1
      UniProtKB/TrEMBL
      B7Z7Y5
      Related
      ENSP00000385093.4, ENST00000407050.8
      Conserved Domains (4) summary
      cd09562
      Location:821 → 891
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:918 → 983
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1003 → 1074
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 459
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. NM_001220478.2 → NP_001207407.1  liprin-alpha-2 isoform g

      See identical proteins and their annotated locations for NP_001207407.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has multiple differences in the 5' UTR and coding region, compared to variant 1. It encodes isoform g, which is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK294505, AL713132, AW304872, BM661844, CB051855, DA687865, DC321269, EL947964
      Consensus CDS
      CCDS55852.1
      UniProtKB/TrEMBL
      B7Z7Y5
      Related
      ENSP00000327416.8, ENST00000333447.11
      Conserved Domains (5) summary
      cd09562
      Location:796 → 866
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:914 → 979
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:999 → 1070
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:94 → 434
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:323 → 589
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    7. NM_001220479.3 → NP_001207408.1  liprin-alpha-2 isoform h

      See identical proteins and their annotated locations for NP_001207408.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has multiple differences in the 5' UTR and coding region, compared to variant 1. It encodes isoform h, which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK296380, AW304872, BM661844, CB051855, EL947964
      Consensus CDS
      CCDS55851.1
      UniProtKB/Swiss-Prot
      O75334
      Related
      ENSP00000438337.2, ENST00000541570.6
      Conserved Domains (4) summary
      cd09562
      Location:462 → 532
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:555 → 620
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:640 → 711
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:7 → 264
      SMC_N; RecF/RecN/SMC N terminal domain

    8. NM_001220480.3 → NP_001207409.1  liprin-alpha-2 isoform i

      See identical proteins and their annotated locations for NP_001207409.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) has multiple differences in the 5' UTR and coding region but maintains the reading frame, compared to variant 1. This results in a shorter protein (isoform i), compared to isoform a.
      Source sequence(s)
      AK123372, AW304872, BM689808, CB051855, DC322478, EL947964
      Consensus CDS
      CCDS55850.1
      UniProtKB/Swiss-Prot
      O75334
      Related
      ENSP00000445532.1, ENST00000541017.5
      Conserved Domains (3) summary
      cd09562
      Location:112 → 182
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:205 → 270
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:290 → 361
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

    9. NM_001282536.1 → NP_001269465.1  liprin-alpha-2 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate 5' exon structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (j) with a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK302658, AW304872, BM661844, BU568524, CB051855, DB083201, EL947964
      Consensus CDS
      CCDS73503.1
      UniProtKB/TrEMBL
      B7Z7Y5, H0YHK3
      Related
      ENSP00000447273.2, ENST00000550359.6
      Conserved Domains (4) summary
      cd09562
      Location:742 → 812
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:866 → 931
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:951 → 1022
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:36 → 380
      SMC_N; RecF/RecN/SMC N terminal domain

    10. NM_003625.5 → NP_003616.2  liprin-alpha-2 isoform a

      See identical proteins and their annotated locations for NP_003616.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC079408, AF034799, AW304872, BM661844, CB051855, DA329958, DA368637, DA533482, EL947964
      Consensus CDS
      CCDS55857.1
      UniProtKB/Swiss-Prot
      B3KVT5, B3KXA0, B7Z2A6, B7Z3U9, B7Z663, B7ZKZ5, E7ERB8, E7ETG6, F8VP68, O75334, Q2M3G8
      UniProtKB/TrEMBL
      Q4LE62
      Related
      ENSP00000450337.1, ENST00000549396.6
      Conserved Domains (4) summary
      cd09562
      Location:895 → 965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1019 → 1084
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1104 → 1175
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:201 → 533
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      81257975..81759350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449242.2 → XP_024305010.1  liprin-alpha-2 isoform X30

      UniProtKB/TrEMBL
      Q4LE62
      Conserved Domains (4) summary
      cd09562
      Location:895 → 965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:988 → 1053
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1073 → 1144
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:201 → 533
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_017020107.3 → XP_016875596.1  liprin-alpha-2 isoform X27

      UniProtKB/TrEMBL
      Q4LE62

    3. XM_024449240.2 → XP_024305008.1  liprin-alpha-2 isoform X14

      UniProtKB/TrEMBL
      Q4LE62
      Conserved Domains (4) summary
      cd09562
      Location:895 → 965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1009 → 1074
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1094 → 1165
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:201 → 533
      SMC_N; RecF/RecN/SMC N terminal domain

    4. XM_017020090.3 → XP_016875579.1  liprin-alpha-2 isoform X11

      UniProtKB/TrEMBL
      Q4LE62

    5. XM_017020086.2 → XP_016875575.1  liprin-alpha-2 isoform X7

      UniProtKB/TrEMBL
      G3V200, Q4LE62
      Conserved Domains (4) summary
      cd09562
      Location:895 → 965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1019 → 1084
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1104 → 1175
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:201 → 533
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_017020108.3 → XP_016875597.1  liprin-alpha-2 isoform X29

      UniProtKB/TrEMBL
      Q4LE62

    7. XM_047429786.1 → XP_047285742.1  liprin-alpha-2 isoform X20

      UniProtKB/TrEMBL
      Q4LE62

    8. XM_047429781.1 → XP_047285737.1  liprin-alpha-2 isoform X12

      UniProtKB/TrEMBL
      Q4LE62

    9. XM_047429778.1 → XP_047285734.1  liprin-alpha-2 isoform X9

      UniProtKB/TrEMBL
      Q4LE62

    10. XM_047429775.1 → XP_047285731.1  liprin-alpha-2 isoform X5

      UniProtKB/TrEMBL
      Q4LE62

    11. XM_017020099.2 → XP_016875588.1  liprin-alpha-2 isoform X19

      UniProtKB/TrEMBL
      Q4LE62

    12. XM_017020105.2 → XP_016875594.1  liprin-alpha-2 isoform X26

      UniProtKB/TrEMBL
      Q4LE62

    13. XM_047429791.1 → XP_047285747.1  liprin-alpha-2 isoform X31

      UniProtKB/TrEMBL
      Q4LE62

    14. XM_017020103.3 → XP_016875592.1  liprin-alpha-2 isoform X22

      UniProtKB/TrEMBL
      Q4LE62

    15. XM_017020088.2 → XP_016875577.1  liprin-alpha-2 isoform X10

      UniProtKB/TrEMBL
      Q4LE62

    16. XM_047429788.1 → XP_047285744.1  liprin-alpha-2 isoform X23

      UniProtKB/TrEMBL
      Q4LE62

    17. XM_047429785.1 → XP_047285741.1  liprin-alpha-2 isoform X18

      UniProtKB/TrEMBL
      Q4LE62

    18. XM_017020094.3 → XP_016875583.1  liprin-alpha-2 isoform X16

      UniProtKB/TrEMBL
      Q4LE62

    19. XM_024449241.2 → XP_024305009.1  liprin-alpha-2 isoform X28

      UniProtKB/TrEMBL
      Q4LE62
      Conserved Domains (4) summary
      cd09562
      Location:895 → 965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:982 → 1047
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1067 → 1138
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:201 → 533
      SMC_N; RecF/RecN/SMC N terminal domain

    20. XM_047429789.1 → XP_047285745.1  liprin-alpha-2 isoform X24

      UniProtKB/TrEMBL
      Q4LE62

    21. XM_047429783.1 → XP_047285739.1  liprin-alpha-2 isoform X15

      UniProtKB/TrEMBL
      Q4LE62
      Related
      ENSP00000447868.1, ENST00000552948.5

    22. XM_047429777.1 → XP_047285733.1  liprin-alpha-2 isoform X8

      UniProtKB/TrEMBL
      Q4LE62

    23. XM_047429774.1 → XP_047285730.1  liprin-alpha-2 isoform X4

      UniProtKB/TrEMBL
      Q4LE62
      Related
      ENSP00000449338.1, ENST00000548586.5

    24. XM_047429790.1 → XP_047285746.1  liprin-alpha-2 isoform X25

      UniProtKB/TrEMBL
      Q4LE62

    25. XM_047429787.1 → XP_047285743.1  liprin-alpha-2 isoform X21

      UniProtKB/TrEMBL
      Q4LE62

    26. XM_047429784.1 → XP_047285740.1  liprin-alpha-2 isoform X17

      UniProtKB/TrEMBL
      Q4LE62

    27. XM_047429782.1 → XP_047285738.1  liprin-alpha-2 isoform X13

      UniProtKB/TrEMBL
      Q4LE62

    28. XM_047429776.1 → XP_047285732.1  liprin-alpha-2 isoform X6

      UniProtKB/TrEMBL
      Q4LE62

    29. XM_047429773.1 → XP_047285729.1  liprin-alpha-2 isoform X3

      UniProtKB/TrEMBL
      Q4LE62

    30. XM_047429770.1 → XP_047285726.1  liprin-alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q4LE62

    31. XM_047429796.1 → XP_047285752.1  liprin-alpha-2 isoform X38

      UniProtKB/TrEMBL
      Q4LE62

    32. XM_047429795.1 → XP_047285751.1  liprin-alpha-2 isoform X37

      UniProtKB/TrEMBL
      Q4LE62

    33. XM_047429780.1 → XP_047285736.1  liprin-alpha-2 isoform X10

      UniProtKB/TrEMBL
      Q4LE62

    34. XM_047429772.1 → XP_047285728.1  liprin-alpha-2 isoform X2

      UniProtKB/Swiss-Prot
      B3KVT5, B3KXA0, B7Z2A6, B7Z3U9, B7Z663, B7ZKZ5, E7ERB8, E7ETG6, F8VP68, O75334, Q2M3G8
      UniProtKB/TrEMBL
      Q4LE62

    35. XM_047429771.1 → XP_047285727.1  liprin-alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q4LE62

    36. XM_017020118.2 → XP_016875607.1  liprin-alpha-2 isoform X33

      UniProtKB/TrEMBL
      B7Z7Y5

    37. XM_047429794.1 → XP_047285750.1  liprin-alpha-2 isoform X34

      UniProtKB/TrEMBL
      B7Z7Y5

    38. XM_047429793.1 → XP_047285749.1  liprin-alpha-2 isoform X32

      UniProtKB/TrEMBL
      B7Z7Y5

    39. XM_047429792.1 → XP_047285748.1  liprin-alpha-2 isoform X32

      UniProtKB/TrEMBL
      B7Z7Y5

    40. XM_024449245.2 → XP_024305013.1  liprin-alpha-2 isoform X36

      Conserved Domains (4) summary
      cd09562
      Location:490 → 560
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:614 → 679
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:699 → 770
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:1 → 289
      SMC_N; RecF/RecN/SMC N terminal domain

    41. XM_024449244.2 → XP_024305012.1  liprin-alpha-2 isoform X35

      Conserved Domains (1) summary
      cl25732
      Location:201 → 533
      SMC_N; RecF/RecN/SMC N terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      81236956..81738412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373675.1 → XP_054229650.1  liprin-alpha-2 isoform X30

      UniProtKB/TrEMBL
      Q4LE62

    2. XM_054373672.1 → XP_054229647.1  liprin-alpha-2 isoform X27

      UniProtKB/TrEMBL
      Q4LE62

    3. XM_054373658.1 → XP_054229633.1  liprin-alpha-2 isoform X11

      UniProtKB/TrEMBL
      Q4LE62

    4. XM_054373654.1 → XP_054229629.1  liprin-alpha-2 isoform X7

      UniProtKB/TrEMBL
      G3V200, Q4LE62

    5. XM_054373674.1 → XP_054229649.1  liprin-alpha-2 isoform X29

      UniProtKB/TrEMBL
      Q4LE62

    6. XM_054373665.1 → XP_054229640.1  liprin-alpha-2 isoform X20

      UniProtKB/TrEMBL
      Q4LE62

    7. XM_054373655.1 → XP_054229630.1  liprin-alpha-2 isoform X9

      UniProtKB/TrEMBL
      Q4LE62

    8. XM_054373653.1 → XP_054229628.1  liprin-alpha-2 isoform X5

      UniProtKB/TrEMBL
      Q4LE62

    9. XM_054373664.1 → XP_054229639.1  liprin-alpha-2 isoform X19

      UniProtKB/TrEMBL
      Q4LE62

    10. XM_054373671.1 → XP_054229646.1  liprin-alpha-2 isoform X26

      UniProtKB/TrEMBL
      Q4LE62

    11. XM_054373676.1 → XP_054229651.1  liprin-alpha-2 isoform X31

      UniProtKB/TrEMBL
      Q4LE62

    12. XM_054373667.1 → XP_054229642.1  liprin-alpha-2 isoform X22

      UniProtKB/TrEMBL
      Q4LE62

    13. XM_054373656.1 → XP_054229631.1  liprin-alpha-2 isoform X10

      UniProtKB/TrEMBL
      Q4LE62

    14. XM_054373668.1 → XP_054229643.1  liprin-alpha-2 isoform X23

      UniProtKB/TrEMBL
      Q4LE62

    15. XM_054373663.1 → XP_054229638.1  liprin-alpha-2 isoform X18

      UniProtKB/TrEMBL
      Q4LE62

    16. XM_054373661.1 → XP_054229636.1  liprin-alpha-2 isoform X16

      UniProtKB/TrEMBL
      Q4LE62

    17. XM_054373673.1 → XP_054229648.1  liprin-alpha-2 isoform X28

      UniProtKB/TrEMBL
      Q4LE62

    18. XM_054373669.1 → XP_054229644.1  liprin-alpha-2 isoform X24

      UniProtKB/TrEMBL
      Q4LE62

    19. XM_054373660.1 → XP_054229635.1  liprin-alpha-2 isoform X15

      UniProtKB/TrEMBL
      Q4LE62

    20. XM_054373652.1 → XP_054229627.1  liprin-alpha-2 isoform X4

      UniProtKB/TrEMBL
      Q4LE62

    21. XM_054373670.1 → XP_054229645.1  liprin-alpha-2 isoform X25

      UniProtKB/TrEMBL
      Q4LE62

    22. XM_054373666.1 → XP_054229641.1  liprin-alpha-2 isoform X21

      UniProtKB/TrEMBL
      Q4LE62

    23. XM_054373662.1 → XP_054229637.1  liprin-alpha-2 isoform X17

      UniProtKB/TrEMBL
      Q4LE62

    24. XM_054373659.1 → XP_054229634.1  liprin-alpha-2 isoform X13

      UniProtKB/TrEMBL
      Q4LE62

    25. XM_054373651.1 → XP_054229626.1  liprin-alpha-2 isoform X3

      UniProtKB/TrEMBL
      Q4LE62

    26. XM_054373648.1 → XP_054229623.1  liprin-alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q4LE62

    27. XM_054373684.1 → XP_054229659.1  liprin-alpha-2 isoform X38

      UniProtKB/TrEMBL
      Q4LE62

    28. XM_054373683.1 → XP_054229658.1  liprin-alpha-2 isoform X37

      UniProtKB/TrEMBL
      Q4LE62

    29. XM_054373657.1 → XP_054229632.1  liprin-alpha-2 isoform X10

      UniProtKB/TrEMBL
      Q4LE62

    30. XM_054373650.1 → XP_054229625.1  liprin-alpha-2 isoform X2

      UniProtKB/Swiss-Prot
      B3KVT5, B3KXA0, B7Z2A6, B7Z3U9, B7Z663, B7ZKZ5, E7ERB8, E7ETG6, F8VP68, O75334, Q2M3G8
      UniProtKB/TrEMBL
      Q4LE62

    31. XM_054373649.1 → XP_054229624.1  liprin-alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q4LE62

    32. XM_054373679.1 → XP_054229654.1  liprin-alpha-2 isoform X33

      UniProtKB/TrEMBL
      B7Z7Y5

    33. XM_054373680.1 → XP_054229655.1  liprin-alpha-2 isoform X34

      UniProtKB/TrEMBL
      B7Z7Y5

    34. XM_054373678.1 → XP_054229653.1  liprin-alpha-2 isoform X32

      UniProtKB/TrEMBL
      B7Z7Y5

    35. XM_054373677.1 → XP_054229652.1  liprin-alpha-2 isoform X32

      UniProtKB/TrEMBL
      B7Z7Y5

    36. XM_054373682.1 → XP_054229657.1  liprin-alpha-2 isoform X36

    37. XM_054373681.1 → XP_054229656.1  liprin-alpha-2 isoform X35

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75334.2 GenPept UniProtKB/Swiss-Prot:O75334

    Gene LinkOut

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