YHC1 Yhc1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: YHC1
Official Full Name: Yhc1p
Primary source: SGD:S000004289
Locus tag: YLR298C
See related: AllianceGenome:SGD:S000004289; FungiDB:YLR298C; VEuPathDB:YLR298C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables mRNA binding activity and pre-mRNA 5'-splice site binding activity. Involved in mRNA 5'-splice site recognition. Part of U1 snRNP; U2-type prespliceosome; and commitment complex. Human ortholog(s) of this gene implicated in connective tissue disease; mixed connective tissue disease; and systemic lupus erythematosus. Orthologous to human SNRPC (small nuclear ribonucleoprotein polypeptide C). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

A report on structure-function relations of the Yhc1 subunit and novel genetic interactions of the Yhc1 N-domain mutations.
Title: Structure-function analysis of the Yhc1 subunit of yeast U1 snRNP and genetic interactions of Yhc1 with Mud2, Nam8, Mud1, Tgs1, U1 snRNA, SmD3 and Prp28.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables U1 snRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables pre-mRNA 5'-splice site binding	IBA Inferred from Biological aspect of Ancestor more info
enables pre-mRNA 5'-splice site binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA 5'-splice site recognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA 5'-splice site recognition	IEA Inferred from Electronic Annotation more info
involved_in mRNA 5'-splice site recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of RNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in spliceosomal snRNP assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of U1 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U1 snRNP	IDA Inferred from Direct Assay more info	PubMed
part_of U1 snRNP	IEA Inferred from Electronic Annotation more info
part_of U2-type prespliceosome	IDA Inferred from Direct Assay more info	PubMed
part_of U2-type prespliceosome	IEA Inferred from Electronic Annotation more info
part_of commitment complex	IEA Inferred from Electronic Annotation more info
part_of commitment complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

NP_013401.1

Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site

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The following sections contain reference sequences that belong to a specific genome build. Explain