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    SWD2 WD-repeat containing protein SWD2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853851, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SWD2
    Official Full Name
    WD-repeat containing protein SWD2
    Primary source
    SGD:S000001501
    Locus tag
    YKL018W
    See related
    AllianceGenome:SGD:S000001501; FungiDB:YKL018W; VEuPathDB:YKL018W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CPS35; SAF37
    Summary
    Contributes to histone H3K4 methyltransferase activity. Involved in mRNA 3'-end processing; sno(s)RNA 3'-end processing; and telomere maintenance. Part of Set1C/COMPASS complex and mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human WDR82 (WD repeat domain 82). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SWD2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (404102..405091)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene bifunctional protein farnesyltransferase/protein geranylgeranyltransferase Neighboring gene Mco12p Neighboring gene ATP-dependent 5'-3' DNA helicase HCS1 Neighboring gene F1F0 ATP synthase subunit d

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functions for S. cerevisiae Swd2p in 3' end formation of specific mRNAs and snoRNAs and global histone 3 lysine 4 methylation. Dichtl B, et al. RNA, 2004 Jun. PMID 15146080, Free PMC Article
    2. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Sun ZW, et al. Nature, 2002 Jul 4. PMID 12077605
    3. Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation. Vitaliano-Prunier A, et al. Nat Cell Biol, 2008 Nov. PMID 18849979
    4. The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Cheng H, et al. Mol Cell Biol, 2004 Apr. PMID 15024081, Free PMC Article
    5. Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription. Margaritis T, et al. PLoS Genet, 2012 Sep. PMID 23028359, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Set1 N-terminal region and the COMPASS subunit Swd2, which interact with each other, are both needed for efficient RNA polymerase II C-terminal domain binding in Saccharomyces cerevisiae.
      Title: The Set1 N-terminal domain and Swd2 interact with RNA polymerase II CTD to recruit COMPASS.
    2. We provide evidence that this topological stress contributes to recruit and/or stabilize condensin at Pol III-transcribed genes in the absence of Swd2.2 and Sen1
      Title: RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes.
    3. Swd2.2 opposes condensin-mediated chromosome condensation by facilitating the function of the two CPF-associated phosphatases PP1 and Ssu72.
      Title: CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.
    4. Data suggest that ecruitment of COMPASS subunits PMA1 and RPS13 is dependent upon Set1 and Swd2, a subunit of the essential transcription termination factor APT (associated with Pta1).
      Title: Yeast Swd2 is essential because of antagonism between Set1 histone methyltransferase complex and APT (associated with Pta1) termination factor.
    5. Ubiquitination of SWD2 links H2B ubiquitination to H3K4 trimethylation.
      Title: Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to histone H3K4 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sno(s)RNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WD-repeat containing protein SWD2
    NP_012907.3
    • Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex; required for Set1C stability and optimal activity; COMPASS methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      404102..405091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179584.3 → NP_012907.3  TPA: WD-repeat containing protein SWD2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012907.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXR8, P36104
      UniProtKB/TrEMBL
      A6ZZU7, B3LR67, B5VMD7, C7GRH7, C8ZCF0, G2WI13, N1P0C8
      Conserved Domains (2) summary
      sd00039
      Location:30 → 72
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:28 → 322
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36104.1

    Gene LinkOut

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