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    STR2 cystathionine gamma-synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    STR2
    Official Full Name
    cystathionine gamma-synthase
    Primary source
    SGD:S000003891
    Locus tag
    YJR130C
    See related
    AllianceGenome:SGD:S000003891; FungiDB:YJR130C; VEuPathDB:YJR130C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cystathionine gamma-synthase activity. Involved in transsulfuration. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See STR2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (665218..667137, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein-lysine N-methyltransferase Neighboring gene mannosyl-oligosaccharide 1,2-alpha-mannosidase Neighboring gene Nmd5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary plasticity of methionine biosynthesis. Gophna U, et al. Gene, 2005 Aug 1. PMID 16046084
    2. The yeast TUM1 affects production of hydrogen sulfide from cysteine treatment during fermentation. Huang CW, et al. FEMS Yeast Res, 2016 Dec. PMID 27915245
    3. The alternative pathway of glutathione degradation is mediated by a novel protein complex involving three new genes in Saccharomyces cerevisiae. Ganguli D, et al. Genetics, 2007 Mar. PMID 17179087, Free PMC Article
    4. Cysteine is essential for transcriptional regulation of the sulfur assimilation genes in Saccharomyces cerevisiae. Hansen J, et al. Mol Gen Genet, 2000 Apr. PMID 10821189
    5. Evidence for a pro-oxidant intermediate in the assembly of cytochrome oxidase. Khalimonchuk O, et al. J Biol Chem, 2007 Jun 15. PMID 17430883

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cystathionine gamma-synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cystathionine gamma-synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cystathionine gamma-synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfur compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transsulfuration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transsulfuration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transsulfuration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cystathionine gamma-synthase
    NP_012664.1
    • Cystathionine gamma-synthase, converts cysteine into cystathionine; STR2 has a paralog, YML082W, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      665218..667137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181788.1 → NP_012664.1  TPA: cystathionine gamma-synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012664.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWU8, P47164
      UniProtKB/TrEMBL
      A6ZQ85, B3LQL2, C7GM83, C8ZBS8, N1P8X1
      Conserved Domains (1) summary
      COG0626
      Location:203 → 637
      MetC; Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47164.1

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