BPH1 Bph1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: BPH1
Official Full Name: Bph1p
Primary source: SGD:S000000628
Locus tag: YCR032W
See related: AllianceGenome:SGD:S000000628; FungiDB:YCR032W; VEuPathDB:YCR032W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables small GTPase binding activity. Involved in several processes, including fungal-type cell wall organization; intracellular protein transport; and response to pH. Acts upstream of or within protein lipidation. Located in cytosol. Is active in late endosome. Used to study Chediak-Higashi syndrome. Human ortholog(s) of this gene implicated in Chediak-Higashi syndrome and primary autosomal dominant microcephaly 18. Orthologous to several human genes including WDFY4 (WDFY family member 4). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

associates with a membrane and is involved in protein sorting and cell wall formation
Title: Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein lipidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to pH	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
is_active_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

NP_009961.2

Endosomal protein involved in endocytosis and autophagy; homologous to Chediak-Higashi syndrome and Beige proteins, both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting

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The following sections contain reference sequences that belong to a specific genome build. Explain