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    COX3 cytochrome c oxidase subunit 3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854627, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX3
    Official Full Name
    cytochrome c oxidase subunit 3
    Primary source
    SGD:S000007283
    Locus tag
    Q0275
    See related
    AllianceGenome:SGD:S000007283; FungiDB:Q0275; VEuPathDB:Q0275
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    OXI2
    Summary
    Enables ubiquinone binding activity. Contributes to cytochrome-c oxidase activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in MELAS syndrome. Orthologous to human MT-CO3 (mitochondrially encoded cytochrome c oxidase III). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COX3 in Genome Data Viewer
    Sequence:
    Chromosome: MT; NC_001224.1 (79213..80022)

    Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene tRNA-Val Neighboring gene tRNA-Met Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001224.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assembly of the mitochondrial membrane system. Characterization of the oxi2 transcript and localization of its promoter in Saccharomyces cerevisiae D273-10B. Thalenfeld BE, et al. J Biol Chem, 1983 Jan 10. PMID 6294116
    2. Expression of green fluorescent protein from a recoded gene inserted into Saccharomyces cerevisiae mitochondrial DNA. Cohen JS, et al. Mitochondrion, 2001 Aug. PMID 16120277
    3. mit-Mutations in the structural gene of subunit III of cytochrome oxidase in Saccharomyces cerevisiae. Stephenson G, et al. Biochim Biophys Acta, 1981 May 29. PMID 6264959
    4. Recombinational analysis of oxi2 mutants and preliminary analysis of their translation products in S. cerevisiae. Baranowska H, et al. Curr Genet, 1983 Jun. PMID 24173282
    5. Interaction of integral and peripheral membrane proteins: affinity labeling of yeast cytochrome oxidase by modified yeast cytochrome c. Birchmeier W, et al. Proc Natl Acad Sci U S A, 1976 Dec. PMID 188034, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to cytochrome-c oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to cytochrome-c oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytochrome-c oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquinone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 3
    NP_009328.1
    • Subunit III of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001224.1 Reference assembly

      Range
      79213..80022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_009328.1 cytochrome c oxidase subunit 3 (mitochondrion) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009328.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A0A7P087, P00420, Q9ZZV9
      UniProtKB/TrEMBL
      A0A0G3F1J2, A0A343UW85, A7LCP4
      Conserved Domains (1) summary
      pfam00510
      Location:12 → 269
      COX3; Cytochrome c oxidase subunit III
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00420.3

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