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    SDP1 mitogen-activated protein kinase tyrosine protein phosphatase SDP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SDP1
    Official Full Name
    mitogen-activated protein kinase tyrosine protein phosphatase SDP1
    Primary source
    SGD:S000001375
    Locus tag
    YIL113W
    See related
    AllianceGenome:SGD:S000001375; FungiDB:YIL113W; VEuPathDB:YIL113W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables MAP kinase tyrosine phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity. Involved in cell integrity MAPK cascade. Located in cytoplasm and nucleus. Orthologous to several human genes including DUSP14 (dual specificity phosphatase 14) and DUSP28 (dual specificity phosphatase 28). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SDP1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (150559..151188)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene FG-nucleoporin NUP159 Neighboring gene putative porin POR2 Neighboring gene Hos4p Neighboring gene cytochrome c oxidase subunit Vb

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases. Fox GC, et al. Nature, 2007 May 24. PMID 17495930
    2. YIL113w encodes a functional dual-specificity protein phosphatase which specifically interacts with and inactivates the Slt2/Mpk1p MAP kinase in S. cerevisiae. Collister M, et al. FEBS Lett, 2002 Sep 11. PMID 12220658
    3. The complex genetic and molecular basis of a model quantitative trait. Linder RA, et al. Mol Biol Cell, 2016 Jan 1. PMID 26510497, Free PMC Article
    4. Intracellular mechanism by which genotoxic stress activates yeast SAPK Mpk1. Liu L, et al. Mol Biol Cell, 2018 Nov 15. PMID 30230955, Free PMC Article
    5. Cbk1 kinase and Bck2 control MAP kinase activation and inactivation during heat shock. Kuravi VK, et al. Mol Biol Cell, 2011 Dec. PMID 22031291, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that mutation of any of the two first amino acids in the IYT motif led to a failure of inactive dual-specificity MAPK phosphatases Sdp1 to trap mitogen-activated protein kinase Slt2.
      Title: A conserved non-canonical docking mechanism regulates the binding of dual specificity phosphatases to cell integrity mitogen-activated protein kinases (MAPKs) in budding and fission yeasts.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables MAP kinase tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables catalytic activity, acting on a protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell integrity MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase tyrosine protein phosphatase SDP1
    NP_012153.1
    • Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; SDP1 has a paralog, MSG5, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      150559..151188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179461.1 → NP_012153.1  TPA: mitogen-activated protein kinase tyrosine protein phosphatase SDP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012153.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVH4, P40479
      UniProtKB/TrEMBL
      B3LTW0, B5VKJ7, C7GKN8, N1P2G2
      Conserved Domains (1) summary
      cd14521
      Location:56 → 194
      DSP_fungal_SDP1-like; dual specificity phosphatase domain of fungal dual specificity protein phosphatase SDP1, MSG5, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40479.1

    Gene LinkOut

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