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    PIB2 Pib2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852861, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIB2
    Official Full Name
    Pib2p
    Primary source
    SGD:S000002991
    Locus tag
    YGL023C
    See related
    AllianceGenome:SGD:S000002991; FungiDB:YGL023C; VEuPathDB:YGL023C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-cysteine binding activity; amino acid sensor activity; and phosphatidylinositol-3-phosphate binding activity. Involved in positive regulation of TORC1 signaling. Located in mitochondrion. Is active in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PIB2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (450197..452104, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tryptophan synthase TRP5 Neighboring gene Pgd1p Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 Neighboring gene protein kinase ALK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional mapping of yeast genomes by saturated transposition. Michel AH, et al. Elife, 2017 May 8. PMID 28481201, Free PMC Article
    2. A glutamine sensor that directly activates TORC1. Tanigawa M, et al. Commun Biol, 2021 Sep 17. PMID 34535752, Free PMC Article
    3. Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation. Caligaris M, et al. Elife, 2023 Feb 7. PMID 36749016, Free PMC Article
    4. KAE1 Allelic Variants Affect TORC1 Activation and Fermentation Kinetics in Saccharomyces cerevisiae. Kessi-Pérez EI, et al. Front Microbiol, 2019. PMID 31417508, Free PMC Article
    5. Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains. Burd CG, et al. Mol Cell, 1998 Jul. PMID 9702203

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A glutamine sensor that directly activates TORC1.
      Title: A glutamine sensor that directly activates TORC1.
    2. Data suggest that Pib2 functioning as a putative glutamine sensor in the regulation of TORC1.
      Title: Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membrane.
    3. Pib2 and the EGO complex cooperate to activate TORC1 and connect phosphoinositide 3-kinase (PI3K) signaling and TORC1 activity.
      Title: Pib2 and the EGO complex are both required for activation of TORC1.
    4. These findings show novel roles of PI(3)P and Pib2 in the regulation of TORC1, which in turn promoted Lysosomal membrane permeabilization and nonapoptotic death of stressed cells
      Title: A LAPF/phafin1-like protein regulates TORC1 and lysosomal membrane permeabilization in response to endoplasmic reticulum membrane stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-cysteine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-cysteine binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables amino acid sensor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in bounding membrane of organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pib2p
    NP_011492.3
    • Phosphatidylinositol 3-phosphate binding protein; forms a distinct complex with TORC1, induced by glutamine in a dose-dependent manner, resulting in TORC1 activation, suggesting dual roles as both a glutamine sensor and a direct TORC1 activator; functions as a cysteine sensor involved in TORC1 activation; involved in leucine- and glutamine-responsive TORC1 activation, independent of the Gtr/Ego pathway; related to human PLEKHF1; contains a PI3P binding FYVE domain; similar to Fab1p and Vps27p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      450197..452104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180888.3 → NP_011492.3  TPA: Pib2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011492.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUB4, E9P8Z2, P53191
      UniProtKB/TrEMBL
      A6ZUX0, N1P9S7
      Conserved Domains (1) summary
      smart00064
      Location:446 → 530
      FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53191.1

    Gene LinkOut

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