CHD1 chromatin-remodeling ATPase CHD1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CHD1
Official Full Name: chromatin-remodeling ATPase CHD1
Primary source: SGD:S000000966
Locus tag: YER164W
See related: AllianceGenome:SGD:S000000966; FungiDB:YER164W; VEuPathDB:YER164W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ATP-dependent chromatin remodeler activity; DNA binding activity; and methylated histone binding activity. Involved in several processes, including DNA-templated transcription; double-strand break repair; and regulation of nucleobase-containing compound metabolic process. Located in nucleolar chromatin. Part of SAGA complex and SLIK (SAGA-like) complex. Is active in site of double-strand break. Used to study prostate cancer. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma; developmental and epileptic encephalopathy 94; and prostate cancer. Orthologous to several human genes including CHD1 (chromodomain helicase DNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CHD1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (505392..509798)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT.
Title: Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT.
Bi-directional nucleosome sliding by the Chd1 chromatin remodeler integrates intrinsic sequence-dependent and ATP-dependent nucleosome positioning.
Title: Bi-directional nucleosome sliding by the Chd1 chromatin remodeler integrates intrinsic sequence-dependent and ATP-dependent nucleosome positioning.
Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state.
Title: Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state.
FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner.
Title: FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner.
Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin.
Title: Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin.
Structural basis of nucleosome transcription mediated by Chd1 and FACT.
Title: Structural basis of nucleosome transcription mediated by Chd1 and FACT.
Autoinhibitory elements of the Chd1 remodeler block initiation of twist defects by destabilizing the ATPase motor on the nucleosome.
Title: Autoinhibitory elements of the Chd1 remodeler block initiation of twist defects by destabilizing the ATPase motor on the nucleosome.
Yeast Chd1p Unwraps the Exit Side DNA upon ATP Binding to Facilitate the Nucleosome Translocation Occurring upon ATP Hydrolysis.
Title: Yeast Chd1p Unwraps the Exit Side DNA upon ATP Binding to Facilitate the Nucleosome Translocation Occurring upon ATP Hydrolysis.
The chromatin remodeler Chd1 regulates cohesin in budding yeast and humans.
Title: The chromatin remodeler Chd1 regulates cohesin in budding yeast and humans.
The Chd1 chromatin remodeler forms long-lived complexes with nucleosomes in the presence of ADP.BeF3 (-) and transition state analogs.
Title: The Chd1 chromatin remodeler forms long-lived complexes with nucleosomes in the presence of ADP·BeF(3)(-) and transition state analogs.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent activity, acting on DNA	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent activity, acting on DNA	IEA Inferred from Electronic Annotation more info
enables ATP-dependent chromatin remodeler activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent chromatin remodeler activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables organic cyclic compound binding	IEA Inferred from Electronic Annotation more info
enables rDNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA double-strand break processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated DNA replication	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcriptional start site selection at RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in termination of RNA polymerase I transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in termination of RNA polymerase II transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in termination of RNA polymerase II transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription elongation by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcription elongation by RNA polymerase II	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
part_of SLIK (SAGA-like) complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of histone acetyltransferase complex	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleolar chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in site of double-strand break	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chromatin-remodeling ATPase CHD1

NP_011091.1

Chromatin remodeler that regulates various aspects of transcription; acts in conjunction with Isw1b to regulate chromatin structure, maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; component of both SAGA and SLIK complexes; ATPase motor stimulates DNA unwrapping from nucleosomes; contains two chromodomains, a helicase domain and a DNA-binding domain; human ortholog CHD1 is a prostate cancer tumor suppressor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

505392..509798

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179054.1 → NP_011091.1 TPA: chromatin-remodeling ATPase CHD1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011091.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DM72, P32657

UniProtKB/TrEMBL

C8Z7I6, G2WD50, N1PA64

Conserved Domains (6) summary

cd11660
Location:1175 → 1204

SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

PLN03142
Location:363 → 961

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

cd18664
Location:283 → 341

CD2_tandem_ScCHD1_like; repeat 2 of the paired tandem chromodomains of yeast chromodomain helicase DNA-binding protein 1, and similar proteins

cd18665
Location:175 → 247

CD1_tandem_CHD1_yeast_like; repeat 1 of the paired tandem chromodomains of yeast chromodomain helicase DNA-binding protein 1, and similar proteins

pfam13907
Location:1368 → 1460

DUF4208; Domain of unknown function (DUF4208)

pfam18196
Location:1010 → 1129

Cdh1_DBD_1; Chromodomain helicase DNA-binding domain 1