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    MEI4 Mei4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856768, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MEI4
    Official Full Name
    Mei4p
    Primary source
    SGD:S000001954
    Locus tag
    YER044C-A
    See related
    AllianceGenome:SGD:S000001954; FungiDB:YER044C-A; VEuPathDB:YER044C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in meiotic DNA double-strand break formation. Located in condensed nuclear chromosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MEI4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_001137.3 (238460..239774, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene adenosylhomocysteinase Neighboring gene Erg28p Neighboring gene Aca1p Neighboring gene Spo73p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MEI4, a meiosis-specific yeast gene required for chromosome synapsis. Menees TM, et al. Mol Cell Biol, 1992 Mar. PMID 1545815, Free PMC Article
    2. Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae. Smeal T, et al. Cell, 1996 Feb 23. PMID 8598049
    3. MEI4, a yeast gene required for meiotic recombination. Menees TM, et al. Genetics, 1989 Dec. PMID 2693205, Free PMC Article
    4. Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Keeney S, et al. Cell, 1997 Feb 7. PMID 9039264
    5. Coordination of the initiation of recombination and the reductional division in meiosis in Saccharomyces cerevisiae. Jiao K, et al. Genetics, 1999 May. PMID 10224247, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA-driven condensation assembles the meiotic DNA break machinery.
      Title: DNA-driven condensation assembles the meiotic DNA break machinery.
    2. Mer2, Mei4, and Rec114 form a distinct complex required for double-strand breaks formation.
      Title: Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic DNA double-strand break formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic DNA double-strand break formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mei4p
    NP_010963.1
    • Meiosis-specific protein involved in forming DSBs; involved in double-strand break (DSBs) formation during meiotic recombination; required for chromosome synapsis and production of viable spores

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      238460..239774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180023.1 → NP_010963.1  TPA: Mei4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010963.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLU5, P29467, P87265
      UniProtKB/TrEMBL
      C7GSJ2, C8Z748
      Conserved Domains (1) summary
      pfam13971
      Location:1 → 405
      Mei4; Meiosis-specific protein Mei4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29467.2

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