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    MBA1 Mba1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852483, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MBA1
    Official Full Name
    Mba1p
    Primary source
    SGD:S000000389
    Locus tag
    YBR185C
    See related
    AllianceGenome:SGD:S000000389; FungiDB:YBR185C; VEuPathDB:YBR185C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mitochondrial ribosome binding activity. Involved in positive regulation of mitochondrial translation and protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MBA1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (599123..599959, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene phytoceramidase Neighboring gene uncharacterized protein Neighboring gene Pch2p Neighboring gene putative ribosome biosynthesis protein GDT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MBA1 encodes a mitochondrial membrane-associated protein required for biogenesis of the respiratory chain. Rep M, et al. FEBS Lett, 1996 Jun 17. PMID 8690083
    2. Mba1, a membrane-associated ribosome receptor in mitochondria. Ott M, et al. EMBO J, 2006 Apr 19. PMID 16601683, Free PMC Article
    3. Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae. Preuss M, et al. J Cell Biol, 2001 May 28. PMID 11381092, Free PMC Article
    4. Partial suppression of Oxa1 mutants by mitochondria-targeted signal recognition particle provides insights into the evolution of the cotranslational insertion systems. Funes S, et al. FEBS J, 2013 Feb. PMID 23198851
    5. Yme2, a putative RNA recognition motif and AAA+ domain containing protein, genetically interacts with the mitochondrial protein export machinery. Sharma N, et al. Biol Chem, 2022 Jul 26. PMID 35100666, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mitochondrial ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inner mitochondrial membrane organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane from matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane from matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane from matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mba1p
    NP_009744.3
    • Membrane-associated mitoribosome receptor; involved along with Dpi29p in the cotranslational insertion of nascent polypeptide chains into the inner mitochondrial membrane; associates with nascent polypeptide chains; interacts with Mdm38p and may recruit mRNA-specific translational activators to the mitoribosome; null mutant displays decreased tolerance to mistranslation-induced proteotoxic stress; localizes to the inner mitochondrial membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      599123..599959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178533.3 → NP_009744.3  TPA: Mba1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009744.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQI0, P38300
      UniProtKB/TrEMBL
      B3LMX6, B5VED8, C7GQ27, D3UES9, G2W9I7, N1P6X2
      Conserved Domains (1) summary
      pfam07961
      Location:51 → 278
      MBA1; MBA1-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38300.1

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