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    MGR2 Mgr2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MGR2
    Official Full Name
    Mgr2p
    Primary source
    SGD:S000006019
    Locus tag
    YPL098C
    See related
    AllianceGenome:SGD:S000006019; FungiDB:YPL098C; VEuPathDB:YPL098C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein import into mitochondrial matrix and protein insertion into mitochondrial inner membrane. Located in mitochondrion. Part of TIM23 mitochondrial import inner membrane translocase complex. Orthologous to human ROMO1 (reactive oxygen species modulator 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MGR2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (364386..364727, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Atg21p Neighboring gene Ina17p Neighboring gene tyrosine--tRNA ligase MSY1 Neighboring gene Eri1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion of Mgr2p Affects the Gating Behavior of the TIM23 Complex. Mirzalieva O, et al. Front Physiol, 2018. PMID 30697167, Free PMC Article
    2. The Mgr2 subunit of the TIM23 complex regulates membrane insertion of marginal stop-transfer signals in the mitochondrial inner membrane. Lee S, et al. FEBS Lett, 2020 Mar. PMID 31764998
    3. Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence. Ieva R, et al. Nat Commun, 2013. PMID 24287567
    4. Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane. Ieva R, et al. Mol Cell, 2014 Dec 4. PMID 25454944
    5. A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex. Dunn CD, et al. Mol Biol Cell, 2006 Jan. PMID 16267274, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Mgr2 subunit of the TIM23 complex regulates membrane insertion of marginal stop-transfer signals in the mitochondrial inner membrane.
      Title: The Mgr2 subunit of the TIM23 complex regulates membrane insertion of marginal stop-transfer signals in the mitochondrial inner membrane.
    2. Data propose that Mgr2 functions at the checkpoint for lateral sorting of the TIM23 complex in mitochondria.
      Title: Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane.
    3. Removal of the Mgr2 C-terminal targeting signal by Imp1 is required for TIM23 complex assembly and function.
      Title: Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence.
    4. The Mgr2 is a coupling factor of the presequence translocase crucial for cell growth at elevated temperature and for efficient protein import.
      Title: Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Mgr2p
    NP_015227.1
    • Core component of the TIM23 protein translocase complex; couples Tim21 with the core Tim23 translocase; provides quality control for membrane protein insertion, regulating their release into the inner membrane by the TIM23 complex; required for mitochondrial import of presequence-containing proteins at elevated temperature; forms the translocation path with Tim17p, sealing the lateral opening of the Tim17p cavity; required for viability of cells lacking the mitochondrial genome (petite-negative)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      364386..364727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183912.1 → NP_015227.1  TPA: Mgr2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015227.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3R8, Q02889
      UniProtKB/TrEMBL
      A6ZWF2, B3LKX4, C7GJ53, C8ZIT2, G2WP82, N1NVH0
      Conserved Domains (1) summary
      pfam10247
      Location:14 → 79
      Romo1; Reactive mitochondrial oxygen species modulator 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02889.1

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