GCD1 translation initiation factor eIF2B subunit gamma [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GCD1
Official Full Name: translation initiation factor eIF2B subunit gamma
Primary source: SGD:S000005786
Locus tag: YOR260W
See related: AllianceGenome:SGD:S000005786; FungiDB:YOR260W; VEuPathDB:YOR260W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TRA3
Summary: Enables translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in negative regulation of cellular response to amino acid starvation and regulation of translational initiation. Located in cytosol. Part of eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 3. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GCD1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (813984..815720)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data show that multiple contacts between eIF2gamma and eIF2Bepsilon mediate nucleotide exchange.
Title: Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to guanyl-nucleotide exchange factor activity	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables translation initiation factor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translational initiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2B complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2B complex	IDA Inferred from Direct Assay more info	PubMed
part_of guanyl-nucleotide exchange factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of guanyl-nucleotide exchange factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of guanyl-nucleotide exchange factor complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: translation initiation factor eIF2B subunit gamma

NP_014903.1

Gamma subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

813984..815720

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183679.1 → NP_014903.1 TPA: translation initiation factor eIF2B subunit gamma [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014903.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2W1, P09032, Q08721

UniProtKB/TrEMBL

A6ZP98, B3LJS8, B5VSE1, C7GWC9, C8ZH11, N1NVX3

Conserved Domains (2) summary

cd04652
Location:433 → 513

LbH_eIF2B_gamma_C; eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...

cd04198
Location:3 → 285

eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2