ABZ2 aminodeoxychorismate lyase ABZ2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ABZ2
Official Full Name: aminodeoxychorismate lyase ABZ2
Primary source: SGD:S000004902
Locus tag: YMR289W
See related: AllianceGenome:SGD:S000004902; FungiDB:YMR289W; VEuPathDB:YMR289W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 4-amino-4-deoxychorismate lyase activity. Involved in folic acid biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ABZ2 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (848685..849809)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a putative catalytic mechanism of a unique class of monomeric ADC lyases led by yeast Abz2.
Title: Structure and catalytic mechanism of yeast 4-amino-4-deoxychorismate lyase.
Abz2p is the founder member of a new group of fungal 4-amino-4-deoxychorismate lyases that have no significant homology to its bacterial or plant counterparts. Abz2p form edhomodimers and dimerization was indispensable for its catalytic activity.[Abz2]
Title: A chemogenomic screening of sulfanilamide-hypersensitive Saccharomyces cerevisiae mutants uncovers ABZ2, the gene encoding a fungal aminodeoxychorismate lyase.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 4-amino-4-deoxychorismate lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables 4-amino-4-deoxychorismate lyase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carboxylic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in carboxylic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in folic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in folic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tetrahydrofolate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aminodeoxychorismate lyase ABZ2

NP_014016.1

EC 4.1.3.38

Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase); catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

848685..849809

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182796.1 → NP_014016.1 TPA: aminodeoxychorismate lyase ABZ2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014016.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0B6, Q03266, Q03531

UniProtKB/TrEMBL

A6ZN05, B3LMH7, C7GTL0, C8ZFF6, G2WKZ8, N1P0Q6

Conserved Domains (1) summary

COG0115
Location:38 → 366

IlvE; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]