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    DUS1 tRNA dihydrouridine synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DUS1
    Official Full Name
    tRNA dihydrouridine synthase
    Primary source
    SGD:S000004545
    Locus tag
    YML080W
    See related
    AllianceGenome:SGD:S000004545; FungiDB:YML080W; VEuPathDB:YML080W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA dihydrouridine synthase activity. Involved in tRNA modification. Located in nucleus. Orthologous to human DUS1L (dihydrouridine synthase 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DUS1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (108806..110077)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene F1F0 ATP synthase subunit i Neighboring gene Tda9p Neighboring gene Cff1p Neighboring gene peptidylprolyl isomerase CPR3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. Xing F, et al. J Biol Chem, 2004 Apr 23. PMID 14970222
    2. Rapid tRNA decay can result from lack of nonessential modifications. Alexandrov A, et al. Mol Cell, 2006 Jan 6. PMID 16387656
    3. Selective defects in gene expression control genome instability in yeast splicing mutants. Tam AS, et al. Mol Biol Cell, 2019 Jan 15. PMID 30462576, Free PMC Article
    4. Checkpoint kinase interaction with DNA polymerase alpha regulates replication progression during stress. Hadjicharalambous A, et al. Wellcome Open Res, 2023. PMID 37766847, Free PMC Article
    5. Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins. Hesselberth JR, et al. Genome Biol, 2006. PMID 16606443, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA dihydrouridine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA-dihydrouridine16 synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-dihydrouridine17 synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA dihydrouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    tRNA dihydrouridine synthase
    NP_013631.1
    • Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNAs at U16 and U17 of the D loop

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      108806..110077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182439.1 → NP_013631.1  TPA: tRNA dihydrouridine synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013631.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0K3, P53759
      UniProtKB/TrEMBL
      G2WJX5
      Conserved Domains (1) summary
      pfam01207
      Location:32 → 351
      Dus; Dihydrouridine synthase (Dus)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53759.1

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