Prss8 serine protease 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prss8provided by RGD
Official Full Name: serine protease 8provided by RGD
Primary source: RGD:619973
See related: EnsemblRapid:ENSRNOG00000019616 AllianceGenome:RGD:619973
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CAP1
Summary: Predicted to enable sodium channel regulator activity. Involved in several processes, including positive regulation of sodium ion transmembrane transport; response to mineralocorticoid; and response to peptide hormone. Located in extracellular space. Used to study alopecia. Orthologous to human PRSS8 (serine protease 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 631.5), Lung (RPKM 137.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191966701..191971271, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182536229..182540745, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (199372519..199377035, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity.
Title: Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity.
Data show that apical, GPI-anchored, lipid raft-associated serine protease activity, compatible with prostasin, is necessary for the development of a high-resistance collecting duct epithelium.
Title: Apical serine protease activity is necessary for assembly of a high-resistance renal collecting duct epithelium.
A 12-bp deletion in the third exon of the Prss8 gene is responsible for the mutant 'hairless', frizzy-Charles River (frCR) phenotype. No alterations to Prss8 coding sequences were detected in the allelic 'fuzzy' rat variant.
Title: The mouse frizzy (fr) and rat 'hairless' (frCR) mutations are natural variants of protease serine S1 family member 8 (Prss8).

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General gene information

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Markers

Prss8 (e-PCR), detects polymorphism
- UniSTS:531092

AI179378 (e-PCR)
- UniSTS:250560

RH135325 (e-PCR)
- UniSTS:218602

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to mineralocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in transepithelial transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostasin

Names: channel-activating protease 1; protease, serine, 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138836.1 → NP_620191.1 prostasin precursor

See identical proteins and their annotated locations for NP_620191.1

Status: PROVISIONAL

Source sequence(s)

AB017638

UniProtKB/Swiss-Prot

Q6GSY8, Q9ER01, Q9ES87

Conserved Domains (2) summary

smart00020
Location:44 → 281

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:45 → 284

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...