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    Hsdl1 hydroxysteroid dehydrogenase like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361418, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hsdl1provided by RGD
    Official Full Name
    hydroxysteroid dehydrogenase like 1provided by RGD
    Primary source
    RGD:1308433
    See related
    EnsemblRapid:ENSRNOG00000015576 AllianceGenome:RGD:1308433
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308433
    Summary
    Predicted to be located in intermediate filament cytoskeleton and intracellular membrane-bounded organelle. Predicted to be active in mitochondrion. Orthologous to human HSDL1 (hydroxysteroid dehydrogenase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 82.6), Brain (RPKM 75.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hsdl1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (64524435..64540527, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (47615794..47631892, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (52209403..52225486, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene N-terminal EF-hand calcium binding protein 2 Neighboring gene solute carrier family 38, member 8 Neighboring gene membrane-bound transcription factor peptidase, site 1 Neighboring gene dynein, axonemal, assembly factor 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2, pseudogene 3 Neighboring gene TATA-box binding protein associated factor, RNA polymerase 1 subunit C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human and zebrafish hydroxysteroid dehydrogenase like 1 (HSDL1) proteins are inactive enzymes but conserved among species. Meier M, et al. Chem Biol Interact, 2009 Mar 16. PMID 19026618
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114519

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables steroid dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables steroid dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    inactive hydroxysteroid dehydrogenase-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024896.1 → NP_001020067.1  inactive hydroxysteroid dehydrogenase-like protein 1

      See identical proteins and their annotated locations for NP_001020067.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097457
      UniProtKB/Swiss-Prot
      Q4V8B7
      UniProtKB/TrEMBL
      A0A8L2UJL9, A6IZJ3
      Related
      ENSRNOP00000020860.6, ENSRNOT00000020859.7
      Conserved Domains (1) summary
      cd05356
      Location:67 → 309
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      64524435..64540527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255713.5 → XP_006255775.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006255775.1

      UniProtKB/Swiss-Prot
      Q4V8B7
      UniProtKB/TrEMBL
      A0A8L2UJL9, A6IZJ3
      Conserved Domains (1) summary
      cd05356
      Location:67 → 309
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

    2. XM_039097871.2 → XP_038953799.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q4V8B7
      UniProtKB/TrEMBL
      A0A8L2UJL9, A6IZJ3
      Conserved Domains (1) summary
      cd05356
      Location:67 → 309
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8B7.1 GenPept UniProtKB/Swiss-Prot:Q4V8B7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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