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    Cdca4 cell division cycle associated 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500727, updated on 27-Dec-2024

    Summary

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    Symbol
    Cdca4provided by RGD
    Full Name
    cell division cycle associated 4provided by RGD
    Primary source
    RGD:1563593
    See related
    EnsemblRapid:ENSRNOG00000013898 AllianceGenome:RGD:1563593
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in cell division and positive regulation of DNA-templated transcription. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDCA4 (cell division cycle associated 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 169.7), Spleen (RPKM 112.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdca4 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137713390..137722652, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (131892305..131901571, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137396133..137421283, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene AHNAK nucleoprotein 2 Neighboring gene clathrin binding box of aftiphilin containing 1 Neighboring gene G protein-coupled receptor 132 Neighboring gene keratin-associated protein 5-9-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP). Bennetts JS, et al. Gene, 2006 Jun 7. PMID 16546331
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124732

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle-associated protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037214.1 → NP_001032291.1  cell division cycle-associated protein 4

      See identical proteins and their annotated locations for NP_001032291.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107668
      UniProtKB/TrEMBL
      Q3B7C7
      Related
      ENSRNOP00000088867.1, ENSRNOT00000100777.2
      Conserved Domains (1) summary
      pfam06031
      Location:33 → 68
      SERTA; SERTA motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      137713390..137722652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112764.2 → XP_038968692.1  cell division cycle-associated protein 4 isoform X1

      UniProtKB/TrEMBL
      M0R698
      Related
      ENSRNOP00000064942.2, ENSRNOT00000018596.7
      Conserved Domains (1) summary
      pfam06031
      Location:39 → 74
      SERTA; SERTA motif

    2. XM_039112763.2 → XP_038968691.1  cell division cycle-associated protein 4 isoform X1

      UniProtKB/TrEMBL
      M0R698
      Conserved Domains (1) summary
      pfam06031
      Location:39 → 74
      SERTA; SERTA motif

    3. XM_008764948.4 → XP_008763170.1  cell division cycle-associated protein 4 isoform X2

      See identical proteins and their annotated locations for XP_008763170.1

      UniProtKB/TrEMBL
      Q3B7C7
      Related
      ENSRNOP00000100496.1, ENSRNOT00000155559.1
      Conserved Domains (1) summary
      pfam06031
      Location:33 → 68
      SERTA; SERTA motif
    Nucleotide Protein Strain
    Heading Accession and Version

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